Combining Ingredients for Anti-Aging Gel

Yes, you can generally combine Vitamin B3 (Niacinamide), Acetyl Glucosamine, peptides, and Ume Extract in a gel formulation aimed at reducing wrinkles, including for the eye area. These ingredients are known for their complementary benefits in skincare:

• Vitamin B3 (Niacinamide): Helps improve skin barrier function, reduce redness, and improve skin tone and texture.
• Acetyl Glucosamine: Works well with Niacinamide to improve skin tone and hydration.
• Peptides: Various peptides can help support collagen and elastin production, which is crucial for reducing the appearance of wrinkles and improving skin firmness.
• Ume Extract: Known for its anti-glycation properties, which can help protect skin elasticity and reduce the formation of advanced glycation end-products (AGEs) that contribute to skin aging.

When combining these ingredients, ensure they are compatible within your specific formulation's pH range and solvent system.

Regarding the use of Phenonip P4 at 1% in a gel for the eye area, while Phenonip is a broad-spectrum preservative, using it at 1% around the sensitive eye area should be approached with caution. The eye area is delicate and more prone to irritation. It is advisable to:

• Consider using preservatives specifically recommended for eye area products, which are typically milder.
• If using Phenonip P4, start with a lower concentration if possible and perform thorough stability and compatibility testing, especially for eye irritation.
• Always perform patch testing on a small area of skin before applying the final product around the eyes.

Formulating for the eye area requires careful consideration of ingredient concentrations and overall product mildness.