Combining Peptides for Wrinkle and Eye Care (Eyeseryl, REGU-AGE, SNAP-8, Argireline, Matrixyl 3000, Tego Pep 4-17)

Question

I would like to know about the compatibility and recommended combinations of the following ingredients for use in cosmetic formulations aimed at reducing wrinkles and addressing eye area concerns:

Eyeseryl® (Acetyl Tetrapeptide-5)
REGU®-AGE (Hydrolyzed Rice Bran Protein, Glycine Soja (Soybean) Protein, Oxido Reductases)
SNAP-8® (Acetyl Octapeptide-3)
Argireline® (Acetyl Hexapeptide-8)
Matrixyl™ 3000 (Pal-GHK, Pal-GQPR)
Tego® Pep 4-17 (related to Palmitoyl Pentapeptide-4)

Specifically, can Eyeseryl® and REGU®-AGE be used together for eye concerns? And how should the muscle relaxant peptides (SNAP-8®, Argireline®) be combined with collagen stimulating peptides (Matrixyl™ 3000, Tego® Pep 4-17) for wrinkle treatment? Should ingredients from the same functional group be combined?

MySkinRecipes Expert · Accepted Answer

Ingredient Combinations for Wrinkle and Eye Care

Based on your questions and the information provided, here is a summary regarding the use and combination of the ingredients you mentioned:

Eyeseryl® vs. REGU®-AGE

Eyeseryl® (Acetyl Tetrapeptide-5) and REGU®-AGE (Hydrolyzed Rice Bran Protein, Glycine Soja (Soybean) Protein, Oxido Reductases) are both aimed at addressing concerns around the eyes, such as dark circles and puffiness. While their objective is similar, they work through different mechanisms. They can be used together to potentially enhance the effect. However, it is recommended to try REGU®-AGE first, as it is often more cost-effective and has shown good results.

SNAP-8® / Argireline® and Matrixyl™ 3000 / Tego® Pep 4-17

These ingredients fall into two different categories based on their function:

Muscle Relaxants (like Botox): This group includes Argireline® (Acetyl Hexapeptide-8) and SNAP-8® (Acetyl Octapeptide-3). They work by reducing muscle contractions, which helps to relax expression lines and wrinkles.
Collagen Stimulators: This group includes Matrixyl™ 3000 (Pal-GHK, Pal-GQPR) and peptides like Palmitoyl Pentapeptide-4 (found in products like Pep®-PP4, which is related to the Tego® Pep 4-17 group). These ingredients stimulate the skin to produce more collagen and other components essential for skin firmness and youthfulness.

Combination Recommendations:

If you already have wrinkles, it is beneficial to use ingredients from both groups together (a muscle relaxant like Argireline® or SNAP-8®, and a collagen stimulator like Matrixyl™ 3000 or Palmitoyl Pentapeptide-4). This provides a dual approach to wrinkle reduction.
If you do not have wrinkles yet and are focusing on prevention and maintaining skin youthfulness, using only ingredients from the collagen stimulator group (Matrixyl™ 3000 or Palmitoyl Pentapeptide-4) is sufficient.
Within the same group, you should generally choose only one ingredient. For example, use either Argireline® or SNAP-8®, but not both, as they work via similar mechanisms, and combining them may not provide significant additional benefits. The same applies to Matrixyl™ 3000 and Palmitoyl Pentapeptide-4; choose one from this group.

In summary, combine ingredients from different functional groups (muscle relaxant + collagen stimulator) if you have wrinkles, but choose only one ingredient from within each functional group.