Combining Whitening Ingredients in a Base

Yes, you can combine the listed whitening ingredients into a base like Transderm. The key is to incorporate each ingredient into the appropriate phase (water or oil) based on its solubility before combining the phases to form the final product.

Here is a breakdown of the ingredients and their typical solubility:

• Alpha Arbutin (2%): This is water-soluble. The requested concentration is within the recommended usage rate of 0.2-2%.
• N-Acetyl D-Glucosamine (4%): This is water-soluble. The requested concentration is within the recommended usage rate of 1-8%.
• Vitamin B3 (Niacinamide) (4%): This is water-soluble. The requested concentration is within the recommended usage rate of 1-10%.
• Tranexamic Acid (3%): This is water-soluble. The requested concentration is within the recommended usage rate of up to 3% for cosmetic registration.
• Bisabolol (1%): As you noted, this is oil-soluble. The requested concentration is within the recommended usage rate of 0.5-1%.

Mixing Method:

1. Dissolve the water-soluble ingredients (Alpha Arbutin, N-Acetyl D-Glucosamine, Vitamin B3, Tranexamic Acid) in the water phase of your base.
2. Dissolve the oil-soluble ingredient (Bisabolol) in the oil phase of your base.
3. Combine the water phase and oil phase according to the instructions for your specific base to create the final emulsion.

Ensure the pH of the final formulation is suitable for the ingredients, generally within the range of 3.5-6.5 for Alpha Arbutin and 3-8 for Vitamin B3 and Tranexamic Acid. N-Acetyl D-Glucosamine prefers a pH of 3-7. Maintaining the pH within these ranges helps ensure the stability and effectiveness of the active ingredients.