Comparing Poloxamer 407 and Polysorbate 20 (Tween 20) for Mouthwash

When choosing between Poloxamer 407 and Polysorbate 20 for a mouthwash formulation, both can function as solubilizers to incorporate oil-based ingredients like flavors or essential oils into the water base. However, they have different characteristics that make one potentially more suitable than the other for oral care products.

Poloxamer 407

• Pros:
  • Often preferred for oral care applications due to its mild taste and minimal impact on mouthfeel. It generally provides a smoother feel compared to polysorbates.
  • Effective solubilizer, often working at lower concentrations (typically 0.1-5.0%).
  • Dissolves well in water.
• Cons:
  • May be more expensive than Polysorbate 20.
  • Lower usage rate range might require more precise measurement.

Polysorbate 20 (Tween 20)

• Pros:
  • Widely available and commonly used in cosmetic and personal care products.
  • Soluble in water and glycerin (a common mouthwash ingredient).
  • Can effectively solubilize flavors and oils.
  • Products like HiPure™ PS20 offer controlled impurity levels.
• Cons:
  • Can sometimes impart a bitter or soapy taste, especially at higher concentrations, which can be undesirable in a mouthwash.
  • May cause turbidity if not used at a sufficient concentration to fully solubilize the oil phase.
  • Requires a higher typical usage rate (1-20%) compared to Poloxamer 407.

Conclusion for Mouthwash

For a mouthwash formulation where taste and mouthfeel are critical, Poloxamer 407 is generally the favored choice. Its ability to effectively solubilize ingredients with less impact on taste makes it highly suitable for oral care. While Polysorbate 20 can be used, formulators should carefully evaluate its potential to cause off-tastes or a soapy sensation and ensure adequate concentration for clarity.

Consider using Poloxamer 407 for a more palatable mouthwash, or test Polysorbate 20 carefully in your specific formula to ensure acceptable taste and clarity.