Comparison of Penetration Enhancers and Phospholipid Usage
Asked by: shoppingist
On: February 04, 2017
Product Type:
Cosmetics
Question
Regarding penetration enhancers for water-soluble active ingredients:
- If comparing Phospholipid (Hydrogenated Lecithin) vs. 1,2-Hexanediol vs. PE-1 Aqua, which one is the most effective for absorption/penetration of water-soluble active ingredients into the skin?
- If using Phospholipid (Hydrogenated Lecithin) as a penetration enhancer in a formula:
- What is the recommended usage percentage?
- Is it necessary to use a blender or homogenizer for mixing?
Answer
Regarding your questions about the properties of Phospholipid (Hydrogenated Lecithin), particularly concerning its ability to enhance the penetration of water-soluble active ingredients:
- Comparison of Penetration Enhancement: Based on the information available, a direct comparison of the penetration enhancement effectiveness for water-soluble actives between Phospholipid (Hydrogenated Lecithin), 1,2-Hexanediol, and PE-1 Aqua is not possible due to the lack of direct comparative research results. It is recommended to consider other properties such as skin feel, antimicrobial activity, and ease of formulation when choosing among these ingredients.
- Usage Percentage and Mixing Method for Phospholipid:
- When using Phospholipid (Hydrogenated Lecithin) as a penetration enhancer in a formula, the recommended usage percentage is 2-3%.
- To effectively utilize Phospholipid for penetration enhancement by forming liposomes, it is essential to use a high-speed blender or a homogenizer during the mixing process. This is different from other types of penetration enhancers that may only require simple incorporation into the formula.
