Formulation Compatibility and Mixing

Regarding your questions about combining Linked Papain, Japanese Cedar, and a yeast-derived ingredient for a skin exfoliation formula:

1. Can these three ingredients be mixed together in a base?
   Yes, these ingredients can generally be combined in a water-based formulation. Based on the product descriptions, Linked Papain, Japanese Cedar, and various yeast-derived ingredients (such as Yeast Radiance, Dermal Respiratory Factor, or MYFerment Balance) are typically water-soluble or dispersible and are added to the water phase of a formula.

   It is important to consider the recommended pH ranges for each ingredient to ensure compatibility and optimal activity. Linked Papain works best in a pH range of 5.0-7.0, while Japanese Cedar is recommended for pH 3.5-6.5, and Yeast Radiance for pH 4.0-6.5. Dermal Respiratory Factor and MYFerment Balance also mix in water and recommend avoiding heat. A pH range between 5.0 and 6.5 would likely be suitable for combining these ingredients while maintaining their efficacy and stability.

   Also, note that most of these ingredients recommend avoiding high heat during the mixing process.

2. Is a blender necessary for mixing?
   While simple stirring might be sufficient for some fully soluble ingredients, using a blender or homogenizer is generally recommended when combining multiple active ingredients, especially if some are dispersible rather than truly soluble (like Beta Glucan, which was in the search results) or if the final product requires a smooth, uniform texture. Blending helps ensure that all ingredients are evenly distributed throughout the base, improving the stability and consistency of the final product and preventing potential issues like sedimentation over time.

In summary, these ingredients can be formulated together in a water-based system, paying close attention to pH and temperature. Using a blender or homogenizer is advisable for optimal results.