Cosmetic Ingredient Compatibility and Proportions

Based on the ingredients you've listed, most of them are water-soluble and can be mixed into an Aloe Vera Gel base. However, there are important considerations regarding the proportions and compatibility of some ingredients.

Compatibility and Usage Rates:

• Willow Bark Extract (Natural Salicylic Acid): Your proposed amount (10g in 127g, approx. 7.87%) is within the recommended usage rate of 1-10%. It is water-soluble and should be added at temperatures below 40°C.
• Licorice Extract (Water-Soluble): Your proposed amount (2g in 127g, approx. 1.57%) is within the recommended usage rate of 1-2%. It is water-soluble and should be added at temperatures below 40°C, avoiding heat.
• Witch Hazel (Alcohol Free): Your proposed amount (30g in 127g, approx. 23.6%) is within the recommended usage rate of 10-100%. It is water-soluble and should be added at temperatures below 40°C.
• Marine Plankton: Your proposed amount (3g in 127g, approx. 2.36%) is slightly above the recommended usage rate of 1-2%. While a small excess might be acceptable, it's generally best to stay within the recommended range for optimal performance and safety.
• RETINAT (HyaRetin™): Your proposed amount (2g in 127g, approx. 1.57%) is significantly higher than the recommended usage rate of 0.01-0.1%. Using this ingredient at such a high concentration is strongly discouraged and can potentially cause significant skin irritation and adverse reactions. The proportion of RETINAT must be drastically reduced to be within the recommended range (0.1% or less).
• Aloe Vera Gel (Heavy): This serves as your base. Your proposed amount (70g in 127g, approx. 55.1%) is reasonable for a base.
• Rose Water: Your proposed amount (5g in 127g, approx. 3.9%) is within the recommended usage rate of 1-100%. It is water-soluble.
• Natural Moisturizing Amino Acids: Your proposed amount (5g in 127g, approx. 3.9%) is within the recommended usage rate of 0.5-5% for skin. It is water-soluble and should avoid prolonged stirring/shaking.

Potential Compatibility Issues:

• RETINAT (HyaRetin™) is incompatible with cationic substances. You should verify if the "Pro Polymer" in your Aloe Vera Gel base is cationic. If it is, this combination may not be stable or effective.
• The final pH of the mixture will be influenced by the pH of each ingredient (ranging from 3-7). While most ingredients have overlapping compatible pH ranges, the high concentration of certain ingredients could shift the final pH. The stability of RETINAT (HyaRetin™) is also pH-dependent, although encapsulation helps.

Recommended Adjustments and Considerations:

1. Crucially, reduce the amount of RETINAT (HyaRetin™) to a maximum of 0.1% of the total formulation. For a 127g batch, this would be no more than approximately 0.127g.
2. Consider slightly reducing the Marine Plankton to stay within the 1-2% recommended range.
3. Verify the nature of the Pro Polymer in your Aloe Vera Gel base to ensure compatibility with RETINAT (HyaRetin™).
4. Due to the presence of Rose Water and RETINAT (HyaRetin™), the final product should ideally be stored in the refrigerator to maintain stability and efficacy.
5. When mixing, ensure ingredients sensitive to heat (Willow Bark Extract, Licorice Extract, Witch Hazel) are added when the base is below 40°C. Add powdered ingredients like HyaRetin™ to the water phase and ensure they are fully dissolved.

In summary, while most ingredients can be combined, the high concentration of RETINAT (HyaRetin™) in your proposed formula is a significant concern and must be adjusted. Always follow the recommended usage rates for each ingredient to ensure safety and effectiveness.