Compatibility of Retinal-EZ, Pure-Melatonin, and Vitamin B12

Based on the information reviewed for the three ingredients: Retinal-EZ, Pure-Melatonin, and Vitamin B12, combining these three ingredients in a single formulation is difficult and highly challenging due to several limitations and potential incompatibilities.

Considerations for Combining These Three Ingredients

• Light Sensitivity: All three ingredients (Retinal-EZ, Pure-Melatonin, Vitamin B12) are highly sensitive to light and will degrade quickly upon exposure. The finished product must be packaged in a 100% opaque container to prevent degradation.
• Air Sensitivity: Pure-Melatonin is sensitive to air. Continuous exposure to air can cause it to degrade easily. Packaging should minimize air exposure, such as using an airless pump.
• Heat Sensitivity: All three ingredients should avoid heat during mixing. They should be added in the final step after the formula has cooled down.
• pH Sensitivity:
  • Vitamin B12 has an optimal stability pH range of 4.0-6.5, with the best pH being 5.8.
  • Pure-Melatonin has a relatively broad stable pH range of 4-10.
  • Retinal-EZ (Retinaldehyde) is generally more stable in slightly acidic to neutral pH conditions (around 5-6).
  • Finding the single optimal pH condition for all three ingredients to remain stable simultaneously is very challenging, especially given the narrow range for Vitamin B12.
• Interaction with Other Vitamins: The information for Vitamin B12 explicitly states that it should be avoided with other types of Vitamins such as Vitamin C and some other B Vitamins as they affect the stability of Vitamin B12. Combining Vitamin B12 with Retinal (a Vitamin A derivative) and Melatonin (which is not a B vitamin group) may increase the risk of degradation or undesirable reactions.

Conclusion:

While it might theoretically be possible to attempt to find the most suitable conditions (e.g., pH in the range of 4.0-6.5, avoiding light, heat, and air) for all three ingredients to remain stable, the various sensitivities and the warning regarding the use of Vitamin B12 with other vitamins make combining Retinal-EZ, Pure-Melatonin, and Vitamin B12 in the same formula complex and high-risk. There is a significant chance that one or all of the ingredients will degrade and not provide the expected results.

Therefore, to ensure the efficacy and stability of the product, it is not recommended to combine these three ingredients in the same formulation. It is advisable to consider using them in separate formulas or choosing alternative ingredients that have better compatibility.