Compatibility and Texture Adjustment for Serum in Hyaluronic Acid Gel Base

Subject: Regarding the Gly-Cu-Ec Serum by onc B12 3 formula

Thank you for your question regarding modifying the Gly-Cu-Ec Serum formula with our Hyaluronic Acid Gel Base. Here are the answers to your questions:

1. Compatibility with Hyaluronic Acid Gel Base:

   • Mixing the provided ingredients into a Hyaluronic Acid Gel Base has potential compatibility issues, primarily due to the nature of Hyaluronic Acid as an anionic polymer.
   • Copper Peptide (GHK-Cu): The copper ion (Cu2+) is cationic. Cationic ingredients can interact with anionic polymers like Hyaluronic Acid, potentially causing precipitation, cloudiness, or a significant loss in viscosity. This is the most significant potential issue.
   • Adenosine Triphosphate (ATP): ATP salts introduce electrolytes. High concentrations of electrolytes can reduce the viscosity of Hyaluronic Acid gels by screening the charges on the polymer chains.
   • Glycosaminoglycans Complex: Depending on the specific GAGs in the complex, there might be some interactions, but this is generally less likely to cause severe incompatibility compared to the copper peptide.
   • Other ingredients like Niacinamide, Ethylhexylglycerin, Ethoxydiglycol, and Laurocapram are generally compatible with Hyaluronic Acid bases, provided the pH is suitable (typically 5-7).
   • Recommendation: Due to the potential interactions, especially with Copper Peptide and ATP, it is highly recommended to perform a small-scale test batch first to check for compatibility issues such as precipitation, cloudiness, or significant viscosity changes before making a large batch.

2. Need for additional thickener and use of Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer:

   • The Hyaluronic Acid Gel Base already provides viscosity. Adding the serum ingredients (totaling about 21%) might slightly alter the viscosity, potentially reducing it due to the electrolyte effect from ATP or interactions from GHK-Cu.
   • Whether you need additional thickener depends on your desired final texture and viscosity. The Hyaluronic Acid base itself might be sufficient, or you might need a minor adjustment.
   • Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer is a suitable thickener/emulsifier for this type of system. It is generally compatible with anionic polymers and can help stabilize formulations.
   • Usage Rate: If you decide to add it, a typical usage rate for this copolymer is between 0.5% and 3%. You would need to experiment within this range to achieve your desired viscosity. Note that the presence of electrolytes (from ATP) and potential interactions with GHK-Cu might slightly reduce its thickening efficiency compared to a simple water base.

3. Mixing temperature and speed:

   • This formula can typically be mixed at room temperature.
   • Mixing Speed: Use gentle to moderate stirring. Avoid high shear mixing, as this can degrade the Hyaluronic Acid polymer chains, leading to a loss of viscosity. Gentle stirring is also preferred to avoid incorporating excessive air bubbles into the gel.

We hope this information is helpful! Please remember to perform a small test batch to ensure compatibility before proceeding with a full batch.