Compatibility of Alpha Arbutin (Switzerland) and Hydro-White™

Yes, Alpha Arbutin (Switzerland) can be used in combination with Hydro-White™ (Hydroquinone-Replacer) in the same formulation. These two ingredients work synergistically to provide a more comprehensive skin-brightening effect.

Why they work well together:

1. Complementary Mechanisms:
   • Alpha Arbutin: Primarily inhibits the Tyrosinase enzyme, which is the key enzyme responsible for melanin production.
   • Hydro-White™ (Hydroxyphenoxy Propionic Acid): Works by inhibiting the release and transport of melanin to the skin's surface, addressing pigmentation at a different stage than Arbutin.
2. Solubility: Both ingredients are water-soluble, making them easy to incorporate into water-based products like serums, lotions, or gels.

Formulation Guidelines:

• pH Control: It is crucial to maintain the formulation's pH between 3.5 - 6.5. If the pH exceeds 8, Alpha Arbutin can degrade into hydroquinone, which is restricted in cosmetics.
• Temperature:
  • Hydro-White™ can be dissolved in water heated to 60-80°C to speed up the process.
  • Alpha Arbutin should only be added when the mixture has cooled to below 30°C to maintain its stability.
• Stabilization: Both ingredients are sensitive to oxidation, which can cause the formula to turn brown over time. It is highly recommended to include ActiveProtec™ OX at 0.6-1% to prevent discoloration.

Recommended Usage:

• Alpha Arbutin (Switzerland): 0.2-2% (2% is recommended for maximum whitening efficacy).
• Hydro-White™ (Hydroquinone-Replacer): 1%.
• ActiveProtec™ OX: 0.6-1% (to stabilize the color).