Combining Cosmetic Ingredients: Compatibility Guide

Based on the information available for the ingredients you listed, it is generally possible to combine them in a single cosmetic formulation. However, careful attention must be paid to the formulation's pH and temperature during mixing to ensure stability and effectiveness.

Here are the key considerations for combining these ingredients:

• pH Level: The ideal pH range for a formulation containing these ingredients is between 3.5 and 6.0. This range is suitable for Ethyl Ascorbic Acid, Alpha Arbutin, Apple Stem Cell Extract, RETINAT™, and Plankton Artemia Extract. Alpha Arbutin, in particular, should not be in a formulation with a pH higher than 8 as it can degrade.
• Mixing Temperature: To maintain the stability of temperature-sensitive ingredients like Alpha Arbutin, DMAE, Rosa Hybrid Cell Extract, RETINAT™, and Quick-Coll®, the final mixing step should be performed at a temperature below 30°C. While some ingredients can withstand higher temperatures, keeping the temperature below 30°C accommodates all of them.
• Mixing Method: Most of these ingredients are water-soluble. Ethyl Ascorbic Acid, Ectoine, and Plankton Artemia Extract can be incorporated into the water phase. Ingredients like Apple Stem Cell Extract, DMAE, Rosa Hybrid Cell Extract, RETINAT™, and Quick-Coll® are typically added in the final cooling phase of the formulation below the recommended temperature limit.
• Specific Considerations:
  • If using water in your formulation, it is recommended to include 0.2% Disodium EDTA when using Ethyl Ascorbic Acid to help protect its quality.
  • Avoid combining Ethyl Ascorbic Acid with Vitamin B3 or Zinc PCA.
  • DMAE can cause skin irritation at higher concentrations, especially on thin or sensitive skin. Consider starting with a lower concentration if you have sensitive skin.

By adhering to these guidelines regarding pH and temperature, and considering the specific notes for each ingredient, you can create a stable and effective formulation with the ingredients you listed.