Compatibility of Pep®-GHK2CU1-10000 with Disodium EDTA
Asked by: kanokkorn.thia
On: March 21, 2026
Product Type:
Cosmetics
Question
I have a question regarding Pep®-GHK2CU1-10000 (Bis Tripeptide-1 Copper Acetate, 10000ppm):
- Should this ingredient be avoided when using
Disodium EDTA, similar toCopper Tripeptide?
Answer
Yes, Pep®-GHK2CU1-10000 (Bis Tripeptide-1 Copper Acetate) should not be used with Disodium EDTA, just like Copper Tripeptide-1 (GHK-Cu).
Why they are incompatible:
Both Pep®-GHK2CU1-10000 and Copper Tripeptide-1 are complexes where a copper ion is bound to a peptide. Disodium EDTA is a powerful chelating agent designed to bind metal ions. When combined, the EDTA will pull the copper ion away from the peptide, breaking the complex and significantly reducing its effectiveness or rendering it inactive.
Formulation Guidelines for Copper Peptides:
- Avoid Chelators: Do not use Disodium EDTA or Tetrasodium EDTA in the same formula.
- Optimal pH Range: Maintain the formula's pH between 4.5 and 7.4. Stability decreases if the pH is higher or lower than this range.
- Temperature Control: Add the copper peptide during the final step of mixing when the temperature of the formulation is below 40°C.
- Storage: Products containing these peptides should ideally be stored in a cool place (refrigerated at 4°C - 8°C is often recommended for the raw material itself).
