Recommendations for Preservatives and Antioxidants with Dipeptide Diaminobutyroyl Benzylamide Diacetate

Regarding your question about using Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake eq.) in a water-based, non-viscous formula and selecting compatible preservatives and antioxidants, the product description for Dipeptide Diaminobutyroyl Benzylamide Diacetate indeed lists several incompatibilities.

Specifically, it advises against using the following:

• Preservatives: Potassium Sorbate, Benzyl Alcohol, Dehydroacetic Acid, or any Urea group preservatives.
• Other Ingredients (including some with antioxidant properties): Sodium Metabisulfite, Propylene Glycol, PEG-40 Hydrogenated Castor Oil, and the detergent Disodium Cocoamphodiacetate.

To formulate a stable water-based product without viscosity while avoiding these incompatible ingredients, here are some alternative options for preservatives and antioxidants:

Recommended Preservatives

Consider broad-spectrum preservatives that are effective in water-based systems and are not on the restricted list. Examples include:

• Eye Preserved™ (Polyhexamethylene Biguanide, PHMB): This is a water-soluble preservative suitable for various cosmetic applications and is not listed as incompatible.
• Mild Preserved™ COS: This is another broad-spectrum option suitable for water formulas across a wide pH range, and its components are generally compatible with sensitive ingredients.

Always check the specific usage rate and pH compatibility for the chosen preservative.

Recommended Antioxidants

For antioxidants suitable for a water-based formula that are not Sodium Metabisulfite or other incompatible substances, consider options like:

• Hydroxyacetophenone: This ingredient functions as an antioxidant and preservative booster, is water-soluble, and is not on the restricted list.
• Glutathione (L-Glutathione Reduced): A potent water-soluble antioxidant that can help protect the formula from oxidation and is compatible with the peptide.

These alternatives can help maintain the stability and efficacy of your water-based formulation containing Dipeptide Diaminobutyroyl Benzylamide Diacetate while avoiding the listed incompatible ingredients.

Always perform stability testing on your final formulation to ensure compatibility and efficacy.