Deoxyarbutin (D-Arbutin) Stability in Formulation: Heat, Light, and pH

ถามโดย: b_natthawut เมื่อ: August 07, 2017 ประเภทผลิตภัณฑ์: เครื่องสำอาง

คำถาม

Could you please provide detailed guidance on how to formulate with Deoxyarbutin (D-Arbutin) to ensure its stability, specifically regarding:

  • Tolerance to heat during mixing?
  • Methods to protect it from light degradation?
  • The optimal pH range for the final formulation?
  • Any other recommended practices or ingredients (like ActiveProtec™ OX or Vitamin E Acetate) to enhance its stability and prevent issues like discoloration?

คำตอบ

Formulating with Deoxyarbutin (D-Arbutin) for Stability

To ensure the stability of Deoxyarbutin (D-Arbutin) in your formulation and protect it from degradation by heat and light, follow these guidelines:

  • Mixing Method: Deoxyarbutin is soluble in oil. It should be dissolved in the oil phase of your formulation.
  • Temperature: Use heat between 50-60°C to help dissolve the Deoxyarbutin in the oil phase. Avoid heating above 60°C. If higher temperatures are necessary for other ingredients, minimize the exposure time to prevent the Deoxyarbutin from losing quality.
  • pH Level: The optimal pH range for Deoxyarbutin stability is 5.0-5.8. Ensure your final formulation falls within this range.
  • Enhancing Stability:
    • Consider adding ActiveProtec™ OX at 0.6% to help prevent formula discoloration.
    • Including Vitamin E Acetate at 0.1% can also help improve the stability of Deoxyarbutin.
  • Light Protection: Once the formulation is complete, package the final product in a container that provides good protection against light.
  • Storage: For long-term storage of the raw ingredient, keep it in a refrigerator (or freezer if possible) away from sunlight and moisture, in a tightly sealed container. The shelf life is at least 24 months under proper storage conditions.

By following these steps, you can help maintain the effectiveness and stability of Deoxyarbutin in your cosmetic formulations.

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