Dissolution Method for Capryloyl Salicylic Acid (LHA) and Solubility in Glycerin

Capryloyl Salicylic Acid (LHA) is a lipophilic (oil-soluble) derivative of Salicylic Acid, which means it is poorly soluble in water.

Regarding Glycerin:
No, Capryloyl Salicylic Acid (LHA) is generally not soluble in pure Glycerin. Glycerin is a highly polar, water-miscible solvent, and LHA requires a less polar, oil-based, or alcoholic solvent for proper dissolution.

Recommended Dissolution Method:
LHA should be dissolved in a suitable solvent before being incorporated into the final product. The best solvents are:

1. Alcohol: Ethanol (Ethyl Alcohol) is a very effective solvent. Dissolve the LHA in a small amount of 95% Ethanol.
2. Glycols: Propylene Glycol or Butylene Glycol can be used, often with gentle heating (around 40-50°C) to aid dissolution.
3. Cosmetic Esters/Oils: It can also be dissolved in certain cosmetic esters or oils, such as Caprylic/Capric Triglyceride or Isopropyl Myristate (IPM), especially if the final product is an oil-based serum or emulsion.