Dissolution Method for Capryloyl Salicylic Acid (LHA) and Solubility in Glycerin
Asked by: newbaberry
On: October 08, 2025
Product Type:
Cosmetics
Answered
Question
What is the recommended method for dissolving Capryloyl Salicylic Acid (LHA)?
Specifically, is it possible to dissolve Capryloyl Salicylic Acid in Glycerin?
Answer
Capryloyl Salicylic Acid (LHA) is a lipophilic (oil-soluble) derivative of Salicylic Acid, which means it is poorly soluble in water.
Regarding Glycerin:
No, Capryloyl Salicylic Acid (LHA) is generally not soluble in pure Glycerin. Glycerin is a highly polar, water-miscible solvent, and LHA requires a less polar, oil-based, or alcoholic solvent for proper dissolution.
Recommended Dissolution Method:
LHA should be dissolved in a suitable solvent before being incorporated into the final product. The best solvents are:
- Alcohol: Ethanol (Ethyl Alcohol) is a very effective solvent. Dissolve the LHA in a small amount of 95% Ethanol.
- Glycols: Propylene Glycol or Butylene Glycol can be used, often with gentle heating (around 40-50°C) to aid dissolution.
- Cosmetic Esters/Oils: It can also be dissolved in certain cosmetic esters or oils, such as Caprylic/Capric Triglyceride or Isopropyl Myristate (IPM), especially if the final product is an oil-based serum or emulsion.
