Dissolving Minoxidil Tablets in Butylene Glycol
Question
Can Minoxidil tablets be dissolved in Butylene Glycol? What are the challenges, and is there an alternative method for creating a Minoxidil solution using Butylene Glycol?
Answer
Subject: Regarding Minoxidil and Butylene Glycol as a solvent
Hello,
Regarding your question about using Butylene Glycol to dissolve Minoxidil tablets:
Pure Minoxidil is soluble in various solvents, including water, Ethyl Alcohol, and various glycols like Butylene Glycol.
However, Minoxidil tablets contain other ingredients (excipients) in addition to the pure Minoxidil. These additional components are used to form the tablet and may not dissolve well in Butylene Glycol or other solvents.
Therefore, if you intend to dissolve Minoxidil in Butylene Glycol to create a solution, it is recommended to use Minoxidil in its pure powder form instead of crushed tablets. This ensures proper dissolution of the active ingredient and allows you to avoid using Propylene Glycol if it causes scalp irritation.
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Propylene Glycol (USP)