Ensulizole Solubility and pH Stability in Formulation

Based on the staff reply:

1. Regarding using pH test paper (litmus) to check if Ensulizole has dissolved when adjusting the water pH to 6.8-7.0:
   Yes, you can use pH test paper. While it may not provide decimal precision like a pH meter, it helps estimate the pH range. The dissolution of Ensulizole itself serves as an indicator that the pH is within the appropriate range (6.8-7.0). You should stir or mix while gradually adding acid/base to check for dissolution.

2. Regarding adjusting the pH after dissolving Ensulizole and completing the formulation:
   No, you cannot adjust the pH outside the 6.8-7.0 range after formulation. If the pH is adjusted outside this range, Ensulizole can precipitate.