Formulating a Stable Vitamin C Serum Without Refrigeration

Subject: Vitamin C Serum Formulation Stable at Room Temperature

You're right, L-Ascorbic Acid, the most common form of Vitamin C, is highly unstable, especially in water-based formulations. It oxidizes easily when exposed to water, oxygen, light, and heat, which is why refrigeration is often recommended.

However, there are more stable forms of Vitamin C derivatives available that are better suited for formulations that can be stored at room temperature. These derivatives are less prone to oxidation.

Here are some stable Vitamin C derivatives you can consider:

• Ethyl Ascorbic Acid (Product ID: 833): A highly stable derivative that is soluble in both water and oil.
• Ascorbyl Glucoside (AA2G) (Product ID: 265): Another stable derivative that is activated by enzymes in the skin.
• Ascorbyl Tetraisopalmitate (Perfect-C) (Product ID: 499): An oil-soluble, very stable derivative that is known for good skin penetration.

Alternatively, if you prefer to use L-Ascorbic Acid (Product ID: 133 or 134), you can formulate it in an anhydrous (water-free) base, such as a silicone base, using solvents like Isododecane (Product ID: 228), Butylene Glycol (Product ID: 320), and Ethoxydiglycol (Product ID: 137). This type of formulation significantly improves the stability of L-Ascorbic Acid at room temperature compared to water-based serums, although it may still degrade over a longer period.

To create a Vitamin C serum that doesn't require refrigeration, you can choose to use one of the stable derivatives listed above or formulate L-Ascorbic Acid in an anhydrous base.