Formulation Review: Hydro-White, GlyciWhite, Copper Peptide in Hyaluronic Acid Gel Base

Your proposed formulation using Hydro-White (1%), GlyciWhite (5%), Copper Peptide (1%), and Hyaluronic Acid Gel Base (93%) is a good starting point for a serum or gel product. The percentages add up correctly, and the ingredients are generally compatible with a water-based gel system.

However, there are a few crucial points to address to ensure the safety, stability, and efficacy of your product:

• Preservation is Essential: The Hyaluronic Acid Gel Base is preservative-free. Water-based formulations are highly susceptible to microbial contamination. You must incorporate a suitable broad-spectrum preservative system at the recommended usage rate to prevent bacterial, mold, and yeast growth and ensure the product is safe for use and has a reasonable shelf life.
• Mixing Procedure & Temperature:
  • Hydro-White is a powder that requires heat (60-80°C) to dissolve completely.
  • GlyciWhite is also a powder that dissolves in water but should avoid temperatures above 60°C.
  • Copper Peptide (1000ppm Solution) must be added in the final step when the mixture's temperature is below 40°C to maintain its stability.
  • A recommended approach is to dissolve Hydro-White in a small amount of water or the heated base (if compatible), cool it below 60°C, then dissolve GlyciWhite. Once both are fully dissolved and the mixture is below 40°C, combine with the Hyaluronic Acid Gel Base and finally add the Copper Peptide solution. Ensure thorough mixing after each addition.
• pH Adjustment: Copper Peptide is most stable and effective within a pH range of 4.5 to 7.4. After mixing all ingredients, you must check the final pH of your formulation and adjust it if necessary using a suitable acid (like Lactic Acid or Citric Acid solution) or base (like Sodium Hydroxide solution).
• Preventing Discoloration: The supplier information for Hydro-White suggests adding an antioxidant like ActiveProtec OX (at 1%) to help prevent potential discoloration of the product over time. This is a good practice for formulations containing ingredients prone to oxidation.

In summary, while the combination of active ingredients is promising, you absolutely need to add a preservative system and carefully manage the mixing temperature and final pH to create a stable, safe, and effective product. Consider adding an antioxidant for better long-term stability.