Formulating Vitamin C, E, Ferulic Acid Serum: Solubility and Stability
Question
I am planning to make a serum similar to Skinceutical's formula using the following ingredients and percentages: Vitamin C (L-Ascorbic Acid Ultra-Fine) 10%, Vitamin E (dl-alpha tocopherol) 2%, Ferulic Acid 1%. For the water phase (Purified Water), I plan to add Glycerin 5% and Aloe Vera Extract 5%. Will this formula work? Also, regarding the dissolution of Ferulic Acid, can I use Propylene Glycol to dissolve it? If so, what is the appropriate proportion? Are there any other better alternatives for dissolving Ferulic Acid that you would recommend?
Answer
Formulating a Vitamin C, E, and Ferulic Acid Serum
Regarding your plan to create a serum similar to Skinceutical's Vitamin C, E, and Ferulic Acid formula, your proposed ingredients are a good starting point. However, there are a few key considerations for successful formulation, particularly regarding the solubility of Ferulic Acid.
Viability of Your Proposed Formula
Your formula includes Vitamin C (L-Ascorbic Acid Ultra-Fine), Vitamin E (dl-alpha tocopherol), Pure-Ferulic Acid™, Purified Water, Glycerin, and Aloe Vera Extract. While these ingredients are beneficial, the standard Pure-Ferulic Acid™ is not soluble in water. Your proposed formula is primarily water-based (Purified Water, Glycerin, Aloe Vera Extract), which means the Pure-Ferulic Acid™ powder will not dissolve properly in this system.
Additionally, Vitamin C (L-Ascorbic Acid) requires a low pH (ideally between 3.5 and 4.0) for stability and efficacy. You will need to adjust the pH of your final formula to be within this range. Vitamin E (dl-alpha tocopherol) is oil-soluble, so you will need to find a way to incorporate it into your water-based serum, possibly using a small amount of a suitable solvent or emulsifier.
Dissolving Ferulic Acid
You asked if Propylene Glycol can dissolve Pure-Ferulic Acid™. Based on the product information, Pure-Ferulic Acid™ is soluble in solvents like Ethoxydiglycol or ethanol, but not water. Propylene Glycol is a water-soluble solvent and humectant, but it is not listed as a solvent for Pure-Ferulic Acid™ powder.
For a water-based serum like the one you are planning, a much easier and more effective way to incorporate Ferulic Acid is to use Micromul™ Ferulic Acid. This is a microemulsion form of Ferulic Acid that is designed to be directly soluble in water, making the formulation process much simpler. The recommended usage rate for Micromul™ Ferulic Acid is typically 1-5%, with 2-3% being recommended for anti-aging and antioxidant benefits.
Recommendation
To make your serum viable and easier to formulate, consider replacing Pure-Ferulic Acid™ with Micromul™ Ferulic Acid. You will also need to carefully adjust the pH of your final serum to the optimal range for Vitamin C (L-Ascorbic Acid) (pH 3.5-4.0) and find a method to incorporate the oil-soluble Vitamin E (dl-alpha tocopherol) into your water base.
Your inclusion of Glycerin and Aloe Vera Extract is good for adding moisture and soothing properties to the serum.
Related Products Mentioned
Pure-Ferulic Acid™
Vitamin C (L-ascorbic acid) (Ultra-Fine)
Vitamin E (dl-alpha tocopherol)
Propylene Glycol (USP)
Glycerin (USP/Food Grade)