Formulating Vitamin C, E, Ferulic Acid Serum: Solubility and Stability

ถามโดย: chareeratana เมื่อ: December 01, 2020 ประเภทผลิตภัณฑ์: เครื่องสำอาง

คำถาม

I am planning to make a serum similar to Skinceutical's formula using the following ingredients and percentages: Vitamin C (L-Ascorbic Acid Ultra-Fine) 10%, Vitamin E (dl-alpha tocopherol) 2%, Ferulic Acid 1%. For the water phase (Purified Water), I plan to add Glycerin 5% and Aloe Vera Extract 5%. Will this formula work? Also, regarding the dissolution of Ferulic Acid, can I use Propylene Glycol to dissolve it? If so, what is the appropriate proportion? Are there any other better alternatives for dissolving Ferulic Acid that you would recommend?

คำตอบ

Formulating a Vitamin C, E, and Ferulic Acid Serum

Regarding your plan to create a serum similar to Skinceutical's Vitamin C, E, and Ferulic Acid formula, your proposed ingredients are a good starting point. However, there are a few key considerations for successful formulation, particularly regarding the solubility of Ferulic Acid.

Viability of Your Proposed Formula

Your formula includes Vitamin C (L-Ascorbic Acid Ultra-Fine), Vitamin E (dl-alpha tocopherol), Pure-Ferulic Acid™, Purified Water, Glycerin, and Aloe Vera Extract. While these ingredients are beneficial, the standard Pure-Ferulic Acid™ is not soluble in water. Your proposed formula is primarily water-based (Purified Water, Glycerin, Aloe Vera Extract), which means the Pure-Ferulic Acid™ powder will not dissolve properly in this system.

Additionally, Vitamin C (L-Ascorbic Acid) requires a low pH (ideally between 3.5 and 4.0) for stability and efficacy. You will need to adjust the pH of your final formula to be within this range. Vitamin E (dl-alpha tocopherol) is oil-soluble, so you will need to find a way to incorporate it into your water-based serum, possibly using a small amount of a suitable solvent or emulsifier.

Dissolving Ferulic Acid

You asked if Propylene Glycol can dissolve Pure-Ferulic Acid™. Based on the product information, Pure-Ferulic Acid™ is soluble in solvents like Ethoxydiglycol or ethanol, but not water. Propylene Glycol is a water-soluble solvent and humectant, but it is not listed as a solvent for Pure-Ferulic Acid™ powder.

For a water-based serum like the one you are planning, a much easier and more effective way to incorporate Ferulic Acid is to use Micromul™ Ferulic Acid. This is a microemulsion form of Ferulic Acid that is designed to be directly soluble in water, making the formulation process much simpler. The recommended usage rate for Micromul™ Ferulic Acid is typically 1-5%, with 2-3% being recommended for anti-aging and antioxidant benefits.

Recommendation

To make your serum viable and easier to formulate, consider replacing Pure-Ferulic Acid™ with Micromul™ Ferulic Acid. You will also need to carefully adjust the pH of your final serum to the optimal range for Vitamin C (L-Ascorbic Acid) (pH 3.5-4.0) and find a method to incorporate the oil-soluble Vitamin E (dl-alpha tocopherol) into your water base.

Your inclusion of Glycerin and Aloe Vera Extract is good for adding moisture and soothing properties to the serum.

ผลิตภัณฑ์ที่เกี่ยวข้องที่กล่าวถึง

Aloe Vera Extract (extraction ratio 10:1 FullAssay™)
Aloe Vera Extract (extraction ratio 10:1 FullAssay™)
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Pure-Ferulic Acid™
Pure-Ferulic Acid™
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Vitamin C (L-ascorbic acid) (Ultra-Fine)
Vitamin C (L-ascorbic acid) (Ultra-Fine)
เครื่องสำอาง
Vitamin E (dl-alpha tocopherol)
Vitamin E (dl-alpha tocopherol)
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Propylene Glycol (USP)
Propylene Glycol (USP)
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Glycerin (USP/Food Grade)
Glycerin (USP/Food Grade)
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Purified Water, TDS Limit 1PPM)
Purified Water, TDS Limit 1PPM)
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Micromul™ Ferulic Acid (Microemulsion Ferulic Acid)
Micromul™ Ferulic Acid (Microemulsion Ferulic Acid)
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