Formulation Analysis and Texture for a Multi-Active Gel
คำถาม
I have a proposed formulation with the following ingredients and percentages. Could you please advise on the feasibility of mixing these ingredients, their compatibility, whether anything should be removed or added, and what the texture of the final product would be?
Proposed Formulation:
- Safe-B3™ (Vitamin B3, Niacinamide) - 10.00%
- GlucoBright™ (Acetyl glucosamine) - 4.00%
- CosmoWhite™ (1-Methylhydantoin-2-Imide) - 1.50%
- Encapsulated Retinol (65K.IU/g) - 2.00%
- Adenosine Liposome - 3.00%
- Panthenol (Vitamin B5) ExtraLite™ - 3.00%
- Natural Moisturizing Amino Acids - 3.00%
- Double Hyaluron Liquid - 3.00%
- Reshape Gel™ (Gel Maker) - 4.00%
- Alpha Arbutin (Switzerland) - 2.00%
- Pure-EGCG™ (Green Tea Extract, 98% EGCG) - 2.00%
- WhiteCumin™ (Tetrahydrodiferuloylmethane) - 0.20%
- Mild Preserved Eco™ (Preservative-Free) - 1.00%
- Propylene Glycol - 15.00%
- Glycerin 99.5% - 20.00%
- LipidSoft™ - 8.00%
- MSH White™ (Undecylenoyl phenylalanine) - 2.00%
- Oryzanol (Rice Bran Extract) - 0.50%
- Coenzyme Q10 (Powder) - 0.50%
- Coffee Extract (for anti-cellulite, dark circles, hair loss) - 3.00%
- Distilled Water - Remaining amount
คำตอบ
Formulation Analysis and Recommendations
Based on the ingredients and percentages provided, this formulation aims to address multiple skin concerns including whitening, anti-aging, and moisturization, with a gel texture.
Ingredient Compatibility and Potential Issues
The ingredients in your proposed formula are generally compatible, especially considering the properties of Reshape Gel™ which is tolerant to electrolytes (present in Natural Moisturizing Amino Acids and Coffee Extract) and stable across a wide pH range (2-10). However, several ingredients have specific pH requirements for optimal efficacy and stability:
- Safe-B3™ (Niacinamide): Best at pH 4.0-7.0
- GlucoBright™ (Acetyl Glucosamine): Best at pH 3-7
- Alpha Arbutin: Requires pH 3.5-6.5 (Avoid pH > 8)
- Panthenol ExtraLite™: Best at pH 4.0-7.0
- Oryzanol: Best at pH 4.0-6.5
To ensure the effectiveness and stability of these ingredients, the final formulation's pH should ideally be maintained within the 4.0 to 6.5 range.
Mixing requires careful consideration of heat-sensitive ingredients like Encapsulated Retinol, Pure-EGCG™, and Coenzyme Q10 (Powder). Oil-soluble ingredients like MSH White™, Oryzanol, and Coenzyme Q10 (Powder) need to be dissolved in the oil phase with appropriate heat (MSH White™ at 80°C, Oryzanol and Coenzyme Q10 below 60°C) before being incorporated into the cooled water phase containing the Reshape Gel™ and other water-soluble components.
Suggested Adjustments
The formulation contains a high concentration of multiple potent active ingredients (Niacinamide 10%, Encapsulated Retinol 2%, Alpha Arbutin 2%, MSH White™ 2%, Pure-EGCG™ 2%). While some products can handle high active loads, combining this many potent actives might increase the risk of skin irritation or reduce the overall stability of the product over time. Consider focusing on a slightly lower concentration for some actives or selecting a few key ingredients to target specific concerns more effectively.
- High Humectant Levels: The combined percentage of Glycerin (20%) and Propylene Glycol (15%) is quite high (35%). This can contribute to a sticky or heavy feel on the skin.
- Pure-EGCG™: The 2% concentration is recommended for reducing oily skin. If the primary goal is not oil control, a lower concentration (0.1-0.5%) might be sufficient for its antioxidant benefits.
- Coffee Extract: The 3% concentration is suitable for facial anti-aging or hair loss. If intended for the eye area, a 1% concentration is recommended.
Expected Product Texture
Given the use of Reshape Gel™ at 4% as the primary thickener, combined with high levels of humectants (Glycerin, Propylene Glycol) and emollients (LipidSoft™), the final product is likely to have a viscous, opaque gel or a cream-gel hybrid texture. The Reshape Gel™ will provide a unique "memory gel" property, where the gel returns to its original shape after being disturbed. The high percentage of humectants might result in a slightly sticky feel, which the LipidSoft™ can help to mitigate, providing a smoother application.
ผลิตภัณฑ์ที่เกี่ยวข้องที่กล่าวถึง
Alpha Arbutin (Switzerland)
Safe-B3™ (Vitamin B3, Niacinamide)
GlucoBright™ (Acetyl Glucosamine)
Propylene Glycol (USP)
Glycerin (USP/Food Grade)
Natural Moisturizing Amino Acids (e.q. Prodew 400)
Double Hyaluron Liquid
Panthenol (Vitamin B5) ExtraLite™
Coenzyme Q10 Extra
Reshape Gel™ (Gel Maker, Memory-Gel)
MSH White™ (Undecylenoyl phenylalanine)
WhiteCumin™ (Tetrahydrodiferuloylmethane)
Purified Water, TDS Limit 1PPM)
Mild Preserved Eco™ (Preservative-Free)
Pure-EGCG™ (Green Tea Extract, 98% EGCG)
Encapsulated Retinol (65K.IU/g)
CosmoWhite™ (1-Methylhydantoin-2-Imide)
LipidSoft™ Shine
LipidSoft™ Lux