Formulation Advice for Retinaldehyde, Adenosine, and Clover Flower Extract

Here is some guidance on formulating with the ingredients you mentioned, based on their properties:

1. Retinaldehyde

Retinaldehyde is sensitive to heat and light. The product information indicates that you should avoid using heat during mixing. If your formulation process requires heating other ingredients, add Retinaldehyde at the very end and blend it in without applying heat. It is soluble in oil, so ensure your formulation includes an oil phase where it can dissolve. Using protective ingredients like antioxidants and UV filters, and packaging in light-protective containers, is also crucial for maintaining its stability.

2. Adenosine

The type of Adenosine you are using (Pure-Adenosine™) is a powder that is only slightly soluble in water (not more than 0.5%) and not soluble in oil. It is recommended for use in cream or gel formulations where it can be dispersed, rather than fully dissolved in a watery solution like a toner ("น้ำตบ"). The optimal pH range for this ingredient is 3.5-6.5. If you are experiencing precipitation in a watery solution or even a gel, it is likely due to exceeding its solubility limit in the water phase or the pH being outside the recommended range. For a stable formulation, especially a watery one, you might need to consider alternative forms of Adenosine or different formulation approaches that keep it dispersed rather than relying on full dissolution.

3. Clover Flower Extract (Biochanin A 98%)

This extract is a powder that is soluble in solvents like Isopentyldiol and Dimethyl Isosorbide (DMI). The product information advises storing it in a cool place and not exposing it to light and heat. While it may dissolve with heat, applying heat is not recommended for its stability. Ensure you are using a sufficient amount of Isopentyldiol or consider using DMI to help dissolve it without heat.

In summary, for all three ingredients, minimizing or avoiding heat during the mixing process is important for their stability and effectiveness. Pay close attention to the solubility properties of each ingredient and choose appropriate solvents or formulation types (oil phase for Retinaldehyde, dispersion in cream/gel for Adenosine, Isopentyldiol/DMI for Clover Flower Extract) to achieve dissolution or dispersion without relying on heat.