Formulation Compatibility and Mixing Instructions

The proposed formulation contains several beneficial ingredients for acne and skin health. However, there is a significant incompatibility between White Egg Enzyme (Lysozyme) and Nano Silver.

White Egg Enzyme is a cationic ingredient, meaning it has a positive charge. Nano Silver, particularly certain types like colloidal silver, cannot be used in formulations containing cationic ingredients as it can affect stability and efficacy. Therefore, these two ingredients cannot be combined in the same formula.

To proceed with a stable and effective formulation, you should choose to include either White Egg Enzyme or Nano Silver, but not both. Given the other acne-fighting ingredients in your list (Licorice Extract, AcneBee Extra, Safe-B3), keeping White Egg Enzyme might offer a more comprehensive approach to targeting acne bacteria and inflammation, while removing Nano Silver simplifies compatibility with other ingredients and mixing.

Assuming you choose to remove Nano Silver, here is a suggested mixing method for the remaining ingredients:

Suggested Mixing Method (without Nano Silver)

1. Water Phase: Combine water with Licorice Extract, Safe-B3, Panthenol, and Hydroxyethyl Cellulose.
2. Gel Formation: Heat the water phase to 70°C and slowly add Hydroxyethyl Cellulose while stirring continuously until a gel texture is formed.
3. Cooling: Allow the mixture to cool down to room temperature.
4. Add Heat-Sensitive and pH-Sensitive Ingredients: Once cooled, add White Egg Enzyme, Hi-Quercetin, and AcneBee Extra. Mix thoroughly until all ingredients are fully dispersed or dissolved.
5. pH Adjustment: Check and adjust the pH of the final formulation to be within the range of 4-7. A pH between 5.0-5.5 is generally suitable for the stability and efficacy of most ingredients in this list, including the optimal range for AcneBee Extra and within the acceptable range for White Egg Enzyme and others. Avoid a pH above 6.0 due to Hi-Quercetin.

Notes:

• Hi-Quercetin at a 3% concentration is a dark yellow liquid and will likely impart a noticeable yellow color to your final product. This is normal for this ingredient at this concentration.
• The concentrations of Licorice Extract (1%), Safe-B3 (5%), AcneBee Extra (2%), and Panthenol (3%) are within the recommended usage rates and should be effective without causing issues like irritation (for Safe-B3) or stickiness (for Panthenol).
• Ensure thorough mixing at each step to achieve a homogeneous product.

If you prefer to keep Nano Silver and remove White Egg Enzyme, the mixing method would be similar, but you would add Nano Silver (dispersing powder or mixing liquid) in step 4 and the pH range could be slightly broader (4-6.5), avoiding cationic ingredients throughout the formula.

This revised formulation and mixing method should help you create a stable and effective product targeting acne and improving skin condition.