Proposed Formulation Review

The formulation you've proposed appears feasible based on the recommended usage rates of the ingredients:

• Matrixyl 3000 (Pal-GHK, Pal-GQPR) 5%: This is within the recommended usage range (3-5%).
• Acetyl Hexapeptide-8 (Argireline) 10%: This is within the recommended usage range (3-10%).
• Double Hyaluron Liquid 3%: This concentration is suitable for normal or generally dehydrated skin (recommended 3-5%).
• Xanthan Gum (clear gel type) 1%: This is within the recommended usage range (0.1-2%, with 1% being a common recommendation).
• Water 81%: This serves as the base.

The total percentage is 100%.

Both Matrixyl 3000 and Acetyl Hexapeptide-8 are compatible and often used together in anti-aging formulations. Double Hyaluron Liquid and Xanthan Gum are water-soluble and can form the gel base.

Mixing Instructions:

1. Disperse the Xanthan Gum in the water phase. You can mix it with a small amount of glycerin or oil first (if your formula includes them) to help it disperse more easily before adding to water, or add it directly to water with high-speed stirring until a clear gel forms.
2. Add the Double Hyaluron Liquid to the water/Xanthan Gum gel base.
3. Heat the mixture if necessary for other ingredients (though none listed require high heat), but ensure it cools down to below 40°C before proceeding.
4. In the final step, add the Matrixyl 3000 and Acetyl Hexapeptide-8 to the cooled base (below 40°C).
5. Adjust the pH of the final formulation to be within the range of 3.5 to 6.5 to ensure the stability and efficacy of both peptides.

This combination of ingredients can create a serum or gel aimed at reducing the appearance of wrinkles and providing hydration.