Formulation Review and Compatibility for Serum and Essence
Question
Based on the following formulations for a Serum and an Essence, please review the ingredient compatibility and advise if any adjustments (increase/decrease percentages) are needed.
Serum Formulation:
- Galactomyces Ferment Filtrate (aka. Pitera) 38.2%
- Repair Activator™ Liquid (Bifida Ferment Lysate) 15%
- Perfect-C™ (Ascorbyl Tetraisopalmitate) 10%
- Pal-GHK, Pal-GQPR (eq. Matrixyl 3000) 5%
- Beta Glucan (Saccharomyces cerevisiae extract) 5%
- Skin-mimic™ (Skin Barrier Restoration) 5%
- Licorice Extract (Licochalcone A 1%) 3%
- Hydro Gel (Biosaccharide Gum-1) 3%
- Dimethyl Isosorbide (DMI) 3%
- Phospholipid 3%
- Pure-EGCG™ (Green Tea Extract, 98% EGCG) 2%
- Glycerin 99.5% 2%
- Satin Cream Maker™ 1.5%
- Bakuchiol (Natural Retinol) 1%
- Vitamin E (dl-alpha tocopherol) 1%
- MOIST72™ 1%
- Natural PHA (Gluconolactone) 1%
- Mild Preserved Eco™ (Preservative-Free) 1%
- Disodium EDTA 0.2%
- Protec™ UV (Benzotriazolyl Dodecyl p-Cresol) 0.1%
Essence Formulation:
- น้ำกลั่น ปราศจากเชื้อ 52%
- Butylene Glycol 6%
- Safe-B3™ (Vitamin B3, Niacinamide, Switzerland) 5%
- Natural Moisturizing Amino Acids 5%
- GlucoBright™ (Acetyl glucosamine) 4%
- Willow Bark Extract 3%
- Urea 3%
- Mannitol 3%
- Double Hyaluron Liquid 3%
- Panthenol (Vitamin B5) ExtraLite™ 2%
- Sodium Lactate Plus 2%
- Sodium PCA 50% 2%
- TreMoisture™ (Trehalose) 2%
- Grape Seed Extract (Proanthocyanidins) 2%
- Ethoxydiglycol 2%
- Glycerin 99.5% 2%
- Natural PHA (Gluconolactone) 1%
- Vitamin E (Tocopheryl Acetate) Water-Soluble 1%
- Mild Preserved Eco™ (Preservative-Free) 1%
Answer
Formulation Review: Serum and Essence
Based on the provided formulations for the Serum and Essence, here is an analysis of ingredient compatibility and suggestions for potential adjustments:
Serum Formulation Analysis
This serum formulation contains a high concentration of beneficial active ingredients aimed at anti-aging, brightening, and skin barrier support. The combination of Galactomyces Ferment Filtrate, Bifida Ferment Lysate, Perfect-C (Ascorbyl Tetraisopalmitate), Matrixyl 3000, Bakuchiol, and other extracts and hydrators creates a potent blend.
Compatibility:
- The combination of the ferment filtrates, peptides, and hydrators appears generally compatible.
- Perfect-C (Ascorbyl Tetraisopalmitate) is an oil-soluble Vitamin C derivative. Its description notes it should not be used with Niacinamide or Zinc PCA, neither of which are present in this serum formula, so this is fine. It requires a formula pH of 5.0-5.5 for optimal stability and efficacy. The inclusion of Disodium EDTA is good for chelating metal ions that can degrade Vitamin C.
- Bakuchiol is included as a natural retinol alternative. Its description recommends using it with Dimethyl Isosorbide (DMI) for enhanced penetration, which is present in the formula. It also notes sensitivity to metal ions and recommends a chelating agent like Disodium EDTA (present) and keeping the pH below 6.5, ideally 3.5-6.5. The recommended pH range for Perfect-C (5.0-5.5) falls within the ideal range for Bakuchiol.
- Mild Preserved Eco is a preservative blend compatible with a pH range of 4-9.
Potential Adjustments/Considerations:
- pH Adjustment: The most critical factor for stability and efficacy is the final pH of the serum. To ensure optimal performance of both Perfect-C and Bakuchiol, the final pH of the formulation should be adjusted to be within the range of 5.0-5.5.
- Potency and Sensitivity: This formula is highly concentrated with multiple active ingredients. While these ingredients offer significant benefits, the combination and high percentages could potentially cause irritation, especially for sensitive skin types. It is highly recommended to perform a patch test before using the product on the entire face. Users should consider starting with less frequent application to assess their skin's tolerance.
- Texture: The inclusion of Satin Cream Maker will contribute to the texture. If a different feel is desired, the amount might need adjustment, or an alternative emulsifier/thickener could be considered, ensuring compatibility with the active ingredients.
Essence Formulation Analysis
This essence formulation focuses on hydration, brightening, gentle exfoliation, and skin barrier support with ingredients like Niacinamide, Acetyl Glucosamine, Hyaluronic Acid, and Willow Bark Extract.
Compatibility:
- The combination of Safe-B3 (Niacinamide) and GlucoBright (Acetyl Glucosamine) is well-supported by research for synergistic effects on brightening and skin hydration. The description for GlucoBright specifically mentions using it with Vitamin B3.
- Willow Bark Extract contains natural Salicylic Acid, which provides gentle exfoliation. Its description indicates it should be used in formulas with a pH of 4.0-6.5.
- Safe-B3 (Niacinamide) is most stable and effective in the pH range of 4.0-7.0.
- Double Hyaluron Liquid is compatible with a pH range of 3-9.
- Natural PHA (Gluconolactone) provides mild exfoliation and hydration and is generally compatible, with optimal activity often in slightly acidic conditions.
- Mild Preserved Eco is compatible with a pH range of 4-9.
Potential Adjustments/Considerations:
- pH Adjustment: To ensure the best performance and stability of Niacinamide, Acetyl Glucosamine, and Willow Bark Extract, the final pH of the essence formulation should be adjusted to be within the range of 4.0-6.5.
- Total Percentage: The listed percentages sum to 101%. While this might be a minor rounding discrepancy, it's advisable to re-check the percentages to ensure they add up to exactly 100% for accurate formulation.
- Exfoliation: The combination of Willow Bark Extract and Natural PHA provides exfoliating benefits. Users should be aware of this and use appropriate sun protection. For individuals new to exfoliants or with sensitive skin, starting slowly is recommended.
In summary, both formulations contain effective ingredients with good potential for skin benefits. The primary adjustments needed involve verifying and adjusting the final pH of each product to ensure the stability and optimal activity of the key ingredients. Additionally, users should be advised on the potency of the serum formulation and the exfoliating nature of the essence.
Related Products Mentioned
Pal-GHK, Pal-GQPR (eq Matrixyl 3000)
Safe-B3™ (Vitamin B3, Niacinamide)
GlucoBright™ (Acetyl Glucosamine)
Double Hyaluron Liquid
Perfect-C™ (Ascorbyl Tetraisopalmitate)