Formulation Review: Cream with CysWhite and Vitamin C Derivatives - pH Compatibility Issue

ถามโดย: yaneenart.n เมื่อ: April 18, 2022 ประเภทผลิตภัณฑ์: เครื่องสำอาง

คำถาม

Can this cream formulation containing CysWhite (5%), Ascorbyl Glucoside (3%), Ethyl Ascorbic Acid (2%), Odor Kill (1%), Mild Preserved Eco (1%), ActiveProtec OX (1%), Soft Cream Maker (5%), Almond Oil (5%), and Water (77%) be successfully mixed and formulated?

คำตอบ

Formulation Review

Based on the provided ingredients and percentages, the proposed formula has significant compatibility issues, primarily concerning the pH requirements of the Vitamin C derivatives.

  • Ascorbyl Glucoside (AA-2G) requires a pH range of 6.5-6.8 for optimal stability.
  • Ethyl Ascorbic Acid requires a pH range of 3.5-6.0 for optimal stability.

These two required pH ranges are mutually exclusive. It is not possible to create a single formula where both of these ingredients are stable and effective simultaneously.

Furthermore:

  • The description for Ethyl Ascorbic Acid recommends including Disodium EDTA in water-based formulas for enhanced stability, which is missing from your ingredient list.
  • CysWhite (Cysteamine HCL), although included with recommended additives like Odor-Kill and ActiveProtec OX to help with odor and stability in water, is typically used as a short-contact treatment (applied for 15-30 minutes and then washed off) rather than in a leave-on cream formulation.

Conclusion:

Due to the conflicting pH requirements of Ascorbyl Glucoside and Ethyl Ascorbic Acid, this formula cannot be successfully mixed to ensure the stability and efficacy of both Vitamin C derivatives. Additionally, the typical application method for CysWhite as a wash-off product should be considered.

You may need to revise the formula by selecting only one of the Vitamin C derivatives or by creating separate formulations for ingredients with incompatible pH requirements.

ผลิตภัณฑ์ที่เกี่ยวข้องที่กล่าวถึง

NaturalProfile™ Sweet Almond Oil (Cold-Pressed)
NaturalProfile™ Sweet Almond Oil (Cold-Pressed)
เครื่องสำอาง
Ascorbyl Glucoside (AA-2G Stabilized Vitamin C)
Ascorbyl Glucoside (AA-2G Stabilized Vitamin C)
เครื่องสำอาง
Soft Cream Maker™
Soft Cream Maker™
เครื่องสำอาง
Mild Preserved Eco™ (Preservative-Free)
Mild Preserved Eco™ (Preservative-Free)
เครื่องสำอาง
Odor-Kill™
Odor-Kill™
เครื่องสำอาง
ActiveProtec™ OX
ActiveProtec™ OX
เครื่องสำอาง
CysWhite™ (Cysteamine HCL)
CysWhite™ (Cysteamine HCL)
เครื่องสำอาง