Answer to Questions about Glutathione in Cream

Hello! Regarding your questions about making cream using Glutathione, here is the explanation:

1. Regarding Molecular Size and Skin Penetration:

   • It is true that molecular size affects the ability to penetrate the skin barrier, but solubility and proper formulation are also very important factors.
   • If Glutathione does not dissolve well in the cream base (e.g., sedimentation occurs), it cannot penetrate the skin to be effective at all.
   • Some products, such as Glutathione (L-Glutathione) (Extrasol), are developed with enhanced water solubility to help prevent sedimentation and make the ingredient available for better absorption and activity on the skin.

2. Regarding Storage and Dissolving Temperature:

   • The recommendation to store below 40°C and avoid heat during mixing is to prevent the degradation of Glutathione when exposed to heat for a prolonged period.
   • However, the product information states that using heat at 60-70°C "for a short period of time" can help the Glutathione powder dissolve in water more easily and quickly.
   • Applying high heat for a short duration specifically to aid dissolution generally does not cause significant immediate degradation, unlike long-term storage or prolonged exposure to high temperatures.
   • Therefore, during the preparation steps, you can briefly use heat at 60-70°C to help dissolve the Glutathione powder in the water phase before incorporating it into other parts of the cream, being careful not to leave it at high temperature for an extended duration.

Understanding the properties of each ingredient is very important in formulation development. Have fun making your cream!