GreyReverse™ Usage: Clarifying 2% vs 5% Concentration and Recommended Leave-On Application
Question
I previously inquired about using GreyReverse™ (Palmitoyl Tetrapeptide-20 or PTP20) for home formulation. Based on clinical studies, the effective dose requires only 2% of the raw material (achieving 10ppm of the active peptide PTP20).
GreyReverse™ Usage Guidelines
- Why does the company recommend using GreyReverse™ at 5% (the maximum recommended rate) when the clinical dose is achieved at 2%?
- Regarding the application method, what type of product format is suitable for application directly onto the scalp? Should I use a Scalp Spray or a Scalp Serum/Tonic?
Answer
Re: GreyReverse™ Usage Concentration and Application Method
Thank you for your inquiry regarding the recommended usage rate of GreyReverse™ (Palmitoyl Tetrapeptide-20).
1. Clarification on Concentration (2% vs. 5%)
The difference in concentration relates to the active peptide versus the raw material:
- Clinical Dose: The clinical studies that demonstrated efficacy in reducing white/gray hair used a concentration of 10ppm of the active peptide (Palmitoyl Tetrapeptide-20).
- Raw Material Conversion: This effective concentration of 10ppm PTP20 is achieved by using 2% of the GreyReverse™ raw material.
- Recommended Usage Rate: While 2% meets the clinical minimum, we recommend a usage rate of 5% (the maximum recommended rate) for the GreyReverse™ raw material. This higher concentration ensures maximum efficacy and provides a safety margin, especially for consumer-made formulations where application consistency might vary. Using 5% ensures the scalp receives a concentration well above the clinically proven minimum.
2. Recommended Application Type (Leave-On)
For optimal results, GreyReverse™ must be used in a leave-on product applied directly to the scalp, allowing the active ingredients sufficient time to work.
Recommended Formats:
- Scalp Spray: A light, non-greasy liquid that can be sprayed directly onto the roots and massaged in.
- Scalp Serum/Tonic: A slightly thicker, but still light, liquid formulation applied drop-by-drop to the scalp.
Key Requirement: The product must be designed to be applied directly to the scalp (not just the hair strands) and left on without rinsing. Avoid using this ingredient in rinse-off products like shampoos or conditioners.
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