How to Mix L-Glutathione Reduced Powder into Cream: Solubility and Stability Tips

Yes, Glutathione (L-Glutathione Reduced) can be used in skin creams for its antioxidant and skin-brightening properties.

However, you must dissolve the powder in water first before mixing it into a cream, especially an oil-based product like Vaseline (petroleum jelly).

Mixing Instructions for Glutathione Powder

Glutathione powder is water-soluble but not oil-soluble. If you mix the powder directly into Vaseline or any oil-based cream, it will not dissolve and will leave a gritty, powdery residue on the skin, as you correctly anticipated.

Here is the recommended method for incorporating Glutathione into a cream:

1. Dissolve the Glutathione:

   • Determine the amount of Glutathione you want to use (typically 1-3% of the total cream weight).
   • Dissolve the powder in a minimal amount of distilled water (or a water-based solvent like Propylene Glycol or Glycerin, though water is simplest). Use just enough water to fully dissolve the powder.
   • Important: The water must be cool. The product description advises keeping the temperature below 40°C to prevent the Glutathione from degrading.

2. Incorporate into the Cream:

   • Slowly add the concentrated Glutathione solution (the liquid from step 1) to your Vaseline-based cream or lotion.
   • Mix thoroughly until the solution is fully dispersed and the cream is homogeneous.

Important Considerations for Stability

• Base Compatibility: Pure Vaseline (100% Petroleum Jelly) is an anhydrous (water-free) oil base. It is very difficult to stably mix a water solution into pure Vaseline. This method works best if your "Vaseline cream" is actually a commercial lotion or cream (an emulsion) that already contains water. If you are using pure Vaseline, the solution may separate over time.
• pH Level: Glutathione is most stable and effective in an acidic environment. The optimal pH range for the final product should be between pH 3 and 6. If your cream has a high pH (alkaline), the Glutathione will degrade quickly.
• Storage: To maintain the potency of the final cream, store it in a cool place, away from direct sunlight and heat. The product description recommends storing the raw powder in the refrigerator for long-term preservation.