Scleroglucan: A versatile polysaccharide for pharmaceutical applications
Coviello, T., et al. (2005). Scleroglucan: A versatile polysaccharide for pharmaceutical applications. Molecules.
Hello,
I am currently testing the Hydrolyzed Sclerotium Gum in a water-based formulation, and I have a few questions regarding its incorporation:
Could you please provide the recommended incorporation protocol? Specifically, should it be pre-dispersed in a humectant (like Glycerin) or require high-shear mixing to ensure full hydration?
Thank you for your technical support.
The behavior you are observing with Poly-Protect (Hydrolyzed Sclerotium Gum) is typical for natural polysaccharide gums when incorporated without pre-dispersion. Below is the technical breakdown and recommended protocol to resolve these issues.
A solution of Hydrolyzed Sclerotium Gum at the recommended usage rate (0.5–2%) is typically translucent to slightly opalescent, rather than crystal clear.
The small, transparent particles you see are known as "fish-eyes." These occur when the outer layer of a powder clump hydrates instantly, forming a gelatinous membrane that prevents water from reaching the dry powder inside.
To achieve a smooth, uniform gel without particles, follow this protocol:
| Issue | Cause | Solution |
|---|---|---|
| Cloudiness | Natural property / Air | Normal translucency; allow air to settle. |
| Transparent Particles | Fish-eyes (Incomplete hydration) | Pre-disperse in Glycerin (1:3 ratio). |
| Slow Dissolution | Low shear / No pre-dispersion | Use an overhead mixer or brief homogenization. |
Sources supporting the key technical claims in this answer
Coviello, T., et al. (2005). Scleroglucan: A versatile polysaccharide for pharmaceutical applications. Molecules.
Cargill. Actigum™ CS Sclerotium Gum technical data.