Ingredient Compatibility Assessment

• Copper Peptide (GHK-Cu) and Niacinamide (Safe B3): This is the primary compatibility concern in your formula. It is generally not recommended to combine Copper Peptides and Niacinamide in the same formulation. The interaction between these two ingredients, especially at certain pH levels, can potentially degrade both ingredients, reducing their effectiveness and potentially causing skin irritation. While some formulators attempt to combine them under specific conditions (like a narrow pH range around 6-7 or using encapsulation), for optimal efficacy and safety, it is best to use them in separate products or apply them at different times of the day (e.g., Niacinamide in the morning, Copper Peptide at night).
• Repair Activator™ (Bifida Ferment Lysate): This ingredient is generally compatible with most cosmetic ingredients. The product description indicates it has a pH range of 4-5.5 and should be added in the final step, avoiding heat.
• Glycosaminoglycans Complex: This is a water-soluble ingredient for wrinkle reduction. The product description suggests dissolving it in water at temperatures not higher than 40°C.
• Double hya (Hyaluronic Acid): Hyaluronic Acid is generally compatible with most ingredients. The product descriptions for various types of Hyaluronic Acid indicate stability within a pH range of 3.0-9.0 and temperatures below 70°C. Using different molecular weights (like Standard and Super Low Molecule) is a common strategy for multi-depth hydration.
• Skin-mimic™ (Skin Barrier Restoration): This liposomal ceramide complex is designed to restore the skin barrier and is mixed in the water phase. It is generally compatible with other water-based ingredients.
• GlucoBright™ (Acetyl Glucosamine): This ingredient works well with Niacinamide for whitening and hydration. Its optimal pH range is 3-7, and it should be mixed in the water phase, avoiding prolonged heat.
• Active Protec™ UV: This is a UV and antioxidant blend that is water-soluble and helps protect the formula from degradation. It can be dissolved in water and can handle temperatures up to 60°C.
• DMI (Dimethyl Isosorbide): This is a penetration enhancer that helps deliver other ingredients into the skin. It is compatible with many ingredients and can withstand temperatures up to 80°C. It can help dissolve water-soluble ingredients and enhance the delivery of actives like Niacinamide and Hyaluronic Acid, as noted in its description.
• Dipotassium Glycyrrhizate: This ingredient reduces irritation and strengthens the skin. It is stable within a pH range of 4-7 and should be mixed in the final step below 60°C.
• Odor Kill™: This ingredient helps absorb odors in the formula. It is water-soluble and should be mixed in water, avoiding heat above 50°C. Note that it can also absorb fragrance if present.
• Satin Cream Maker™: This is a heat-free emulsifier and thickener that works over a wide pH range (3-12). It is mixed in the water phase before adding the oil phase.

Conclusion

While most ingredients in your formula appear compatible, the combination of Copper Peptide and Niacinamide (Safe B3) is problematic and can lead to reduced efficacy of both ingredients.

To ensure you get the maximum benefits from all your active ingredients, particularly Copper Peptide and Niacinamide, it is strongly recommended to avoid mixing them in the same formula. You could consider formulating two separate products: one containing Copper Peptide and another containing Niacinamide along with the other compatible ingredients. Alternatively, if you wish to use both, apply them at different times of the day.