Compatibility of Ingredients

Regarding the use of Willow Bark Extract, Double Hyaluron Liquid, and Copper Peptide:

• Willow Bark Extract (Natural Salicylic Acid) and Double Hyaluron Liquid can potentially be formulated together in a cream-gel base, provided the final pH is maintained within a range compatible with both (approximately pH 4.0-6.5 for Willow Bark Extract and pH 3-9 for Double Hyaluron Liquid).
• However, incorporating Copper Peptide into the same formula is challenging. Copper Peptide requires a specific pH range (4.5-7.4) for stability and effectiveness. Combining it with acidic ingredients like Willow Bark Extract can lead to pH issues. Additionally, Copper Peptide is sensitive to chelating agents.
• For optimal efficacy and stability of all ingredients, it is generally recommended to use Copper Peptide in a separate product and apply it at a different time from formulations containing acidic ingredients or chelating agents. You could use the cream-gel with Willow Bark Extract and Double Hyaluron Liquid, and then apply a separate Copper Peptide serum at a different time of day (e.g., Copper Peptide in the morning, the cream-gel in the evening, or vice versa).

Ingredients to Avoid with Copper Peptide

Based on the properties of Copper Peptide, certain ingredients should be avoided in the same formula or used with caution:

• Acidic Ingredients: Strong acids such as Lactic Acid, Glycolic Acid, Citric Acid, and Alpha Lipoic Acid, as well as Vitamin C (especially L-Ascorbic Acid), can lower the pH of the formulation. If the pH falls outside the optimal range of 4.5-7.4, the stability and effectiveness of Copper Peptide can be reduced.
• Chelating Agents: Ingredients that bind metal ions, such as Disodium EDTA, should be avoided in formulas containing Copper Peptide. Disodium EDTA can chelate the copper ion in Copper Peptide, rendering it ineffective.

Therefore, when formulating with Copper Peptide, pay close attention to the pH of the final product and avoid strong chelating agents.