Irritation Risk from Combining Multiple Whitening Agents in Aloe Vera Gel Base

Hello,

Regarding your planned formulation using Pure Aloe Vera Gel as a base and combining multiple whitening agents:

It is true that combining several active ingredients, especially multiple whitening agents, can increase the potential for skin irritation, particularly for individuals with sensitive skin.

Based on the ingredients and concentrations you listed:

• Activated Resorcinol - S™ (5%)
• Active Resveratrol™ (5%)
• N-Acetyl-D Glucosamine (GlucoBright™) (4%)
• Tranexamic Acid (3%)
• WhiteCumin™ 2x (3%)
• SKIN-DEFENSE V® (2%)
• Vitamin B3 (Safe-B3™) (5%)

As the staff reply mentioned, Activated Resorcinol S™ and Tranexamic Acid are ingredients known to potentially cause irritation, especially in sensitive skin. While the concentrations you plan to use (5% and 3% respectively) are within generally accepted limits and help reduce the risk, combining them with other actives increases the overall potential for a reaction.

Using multiple whitening agents aims to target different pathways of melanin production, which can potentially lead to more comprehensive results. However, this approach inherently carries a higher risk of irritation compared to using fewer actives or lower concentrations.

Recommendations:

• If you have sensitive skin or are concerned about irritation, consider following the staff's advice to choose only one of the two potentially more irritating ingredients: Activated Resorcinol S™ or Tranexamic Acid.
• Always perform a patch test on a small, inconspicuous area (like the inner arm) before applying the formulation to your face. Observe for any redness, itching, or discomfort over 24-48 hours.
• Monitor your skin's reaction closely when you start using the full formulation. If irritation occurs, discontinue use or reduce the frequency of application.

While ingredients like N-Acetyl-D Glucosamine, Resveratrol, WhiteCumin, and Vitamin B3 also contribute to brightening and offer other benefits, the combination of many actives at these concentrations requires careful consideration of your skin type and tolerance.

In summary, using multiple whitening agents can increase the risk of irritation. Pay particular attention to Activated Resorcinol and Tranexamic Acid. Follow the staff's recommendation for sensitive skin and always patch test.