L-Ascorbic Acid Solubility Limit in Butylene Glycol for High Concentration Serum

ถามโดย: nbinnima เมื่อ: March 25, 2015 ประเภทผลิตภัณฑ์: เครื่องสำอาง

คำถาม

I want to formulate a serum with L-Ascorbic Acid at a high concentration (10-15%) using Butylene Glycol as the base, similar to some commercial products like cellular skin rx Vitamin C+Firming Serum. However, I understand that L-Ascorbic Acid has limited solubility (around 5%) in Butylene Glycol. How do commercial products achieve these higher concentrations, and what are the limitations when trying to formulate this directly?

คำตอบ

L-Ascorbic Acid Solubility in Butylene Glycol

Based on formulation knowledge and product information, L-ascorbic acid has limited direct solubility in Butylene Glycol, typically not exceeding approximately 5%. Achieving higher concentrations, such as 10-15%, is generally not possible by simply dissolving L-ascorbic acid powder directly into Butylene Glycol, as it will not fully dissolve and may precipitate.

Products like the cellular skin rx Vitamin C+Firming Serum that contain high concentrations of L-ascorbic acid in a glycol base likely utilize specialized or patented processes to achieve stability and solubility, as mentioned in the staff reply. These methods are not standard direct dissolution.

For formulating with L-ascorbic acid, it's important to consider its properties. L-ascorbic acid is highly effective but unstable, particularly in water. Different grades like Vitamin C (L-ascorbic acid) (Ultra-Fine), Vitamin C (L-ascorbic acid) (Fine), and Vitamin C (L-ascorbic acid) (Standard) vary in particle size, affecting dispersion, but their fundamental solubility in solvents like Butylene Glycol remains limited. Other forms of Vitamin C, such as oil-soluble or more stable water-soluble derivatives, might be more suitable depending on the desired formulation and concentration.

If you aim for a high concentration L-ascorbic acid serum, specialized techniques or alternative Vitamin C derivatives designed for better solubility and stability in various bases might be necessary.

ผลิตภัณฑ์ที่เกี่ยวข้องที่กล่าวถึง

Vitamin C (L-ascorbic acid) (Ultra-Fine)
Vitamin C (L-ascorbic acid) (Ultra-Fine)
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Vitamin C (L-ascorbic acid) (Fine)
Vitamin C (L-ascorbic acid) (Fine)
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Butylene Glycol
Butylene Glycol
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Vitamin C (L-ascorbic acid) (Standard)
Vitamin C (L-ascorbic acid) (Standard)
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