Formula Analysis and Substitution

Based on the staff's response, the substituted formula using Hydrogenated Polydecene instead of SNP-Creamflow and SepGEL 305 instead of SNP-Emulbase is unlikely to separate over the long term. The components are considered suitable.

Important Considerations:

• If the oil ratio in the formula is significantly increased, you might need to consider increasing the amount of SepGEL 305.
• The staff suggested replacing Phenoxyethanol with Mild Preserved Eco at 1% for a milder formula.

Proposed Formula with Substitutions and Suggested Preservative Change:

• Water (qs)
• 1,3 Butylene Glycol 2.00%
• Squalane 3.50%
• Hydrogenated Polydecene 5% (replacing SNP-Creamflow 3.00%)
• SepGEL 305 1-2% (replacing SNP-Emulbase 2.50%)
• Novermer EC-1 1.00%
• Hyaluronic Acid 1.00%
• Vitamin B3 3.00%
• Alpha Bisabolol 0.5%
• Mild Preserved Eco 1% (replacing Phenoxyethanol 0.80%)

The staff's analysis indicates that this formulation should be stable over time.