Lotion Formulation with Multiple Actives: Mixing Procedure and Stability
ถามโดย: kwangknowles
เมื่อ: July 23, 2019
ประเภทผลิตภัณฑ์:
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คำถาม
I would like to know if I can use the following active ingredients at these percentages in a formulation, and I need guidance on the mixing procedure:
Active Ingredients and Percentages:
- Activated Resorcinol™ = 1%
- Safe-B3™ (Vitamin B3, Niacinamide) = 4%
- GlucoBright™ (Acetyl glucosamine) = 4%
Please provide recommendations on the mixing procedure, specifically:
- The formulation uses the following phases:
- Phase A: Water-based ingredients
- Phase B: A + Oil-based ingredients
- Phase C: A + B + Active ingredients
- Activated Resorcinol™ needs to be dissolved in oil. Should it be mixed in Phase A (after dissolving in oil) or Phase C?
- Safe-B3™ (Vitamin B3, Niacinamide) dissolves in water. Can it be mixed directly into Phase C?
- GlucoBright™ (Acetyl glucosamine) dissolves in water. Can it be mixed directly into Phase C?
คำตอบ
Suggested Mixing Procedure for Your Lotion
Based on the properties of the active ingredients you plan to use, here is a suggested mixing procedure for your body lotion formulation:
- Activated Resorcinol™ (1%): This ingredient is oil-soluble and should be dissolved in your Phase B (Oil Phase) along with your other oil ingredients and emulsifier before combining with the water phase.
- Safe-B3™ (4%) and GlucoBright™ (4%): Both of these ingredients are water-soluble. Due to their sensitivity to prolonged heat, it is best to add them in the Phase C (Cool-down Phase) after your emulsion has been formed and has cooled down.
Your proposed percentages are within the recommended usage ranges for leave-on products, and the combination of Safe-B3 and GlucoBright is a recommended pairing for skin brightening.
Recommended Mixing Steps:
- Phase A (Water Phase): Combine your water-soluble ingredients (except Safe-B3 and GlucoBright initially) and water. Add Disodium EDTA (recommended at 0.2% for Activated Resorcinol stability). Heat this phase if required by your emulsifier system.
- Phase B (Oil Phase): Combine your oil ingredients and emulsifier. Dissolve the Activated Resorcinol™ (1%) in a small amount of oil or the main oil phase. Heat this phase if required by your emulsifier system.
- Emulsification: Combine Phase A and Phase B according to your emulsifier's instructions (e.g., add oil to water or water to oil while mixing). Mix thoroughly until a stable emulsion is formed. Begin cooling the emulsion.
- Phase C (Cool-down Phase): Once the emulsion has cooled down sufficiently (usually below 40°C), add Safe-B3™ (4%) and GlucoBright™ (4%). Mix well until they are completely dissolved and dispersed in the lotion. Add other cool-down ingredients like preservatives, fragrance, etc.
- Final Adjustment: Check and adjust the pH of the final product to the optimal range for Activated Resorcinol, which is pH 4.5-5.5. This range also falls within the effective pH ranges for Safe-B3 and GlucoBright.
Important Considerations:
- Adding Disodium EDTA is crucial for helping to prevent Activated Resorcinol from discoloring over time.
- Protect the final product from light by using opaque packaging, as Activated Resorcinol is light-sensitive.
- Avoid prolonged heating of the final formula after adding Safe-B3 and GlucoBright.
ผลิตภัณฑ์ที่เกี่ยวข้องที่กล่าวถึง
Safe-B3™ (Vitamin B3, Niacinamide)
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GlucoBright™ (Acetyl Glucosamine)
เครื่องสำอาง
Activated Resorcinol™ (4-Butyl Resorcinol)
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