Ceramide NP Concentration in Formulations

The appropriate concentration of Ceramide NP in a formulation can vary depending on the specific type of Ceramide NP product used and the desired effect.

• For standard Ceramide NP powder (like Ceramide 3 (Ceramide NP)), the typical recommended usage rate is often between 0.01% and 0.2%, with 0.1% being a common recommendation. This aligns with the general guideline you mentioned.
• However, some advanced Ceramide NP products, such as those using delivery systems or encapsulation technology (like Ceracare™ NP50), are designed to be used at higher inclusion rates of the product itself. Ceracare™ NP50 contains 50% Ceramide NP, and its description indicates it can be used at a rate of 0.1-0.5% of the product. Furthermore, stability tests mentioned in its description show stability with additions up to 5% of the product, which corresponds to an actual Ceramide NP content of up to 2.5% in the final formula.

The "skin barrier cream base" you mentioned with 0.8% Ceramide NP likely uses a form of Ceramide NP that allows for a higher concentration, possibly a complex or a product similar to Ceracare™ NP50 used at a higher percentage. While 0.2% is a common recommendation for basic Ceramide NP powder, higher concentrations are indeed used in some specialized formulations, particularly those focused on intensive barrier repair, provided the specific ceramide product is suitable for such levels and the overall formulation is stable and safe.