Mixing Active Ingredients into Hyaluronic Acid Gel Base: Mixing, Storage, and Shelf Life

ถามโดย: kanyawanspa เมื่อ: April 11, 2013 ประเภทผลิตภัณฑ์: เครื่องสำอาง

คำถาม

Based on the provided information regarding mixing active ingredients into a Hyaluronic Acid gel base, I have the following questions:

  • Can I mix the following ingredients together at these specific quantities and use the mixture directly?
    • Hyaluronic Acid gel base (100g)
    • Matrixyl 3000 (5g)
    • Argireline (5g)
    • Alpha Arbutin (2g)
  • What is the recommended storage temperature for this mixture?
  • What is the expected shelf life of the mixture?

คำตอบ

Formulation Mixing and Storage Guide

Yes, you can mix Hyaluronic Acid gel base with Matrixyl 3000, Argireline, and Alpha Arbutin at the quantities you have. The concentrations of the active ingredients in the final mixture will be within the recommended usage rates.

Mixing Instructions

  1. Start with your Hyaluronic Acid gel base (100g).
  2. Weigh out Matrixyl 3000 (5g), Argireline (5g), and Alpha Arbutin (2g).
  3. Add the active ingredients (Matrixyl 3000, Argireline, and Alpha Arbutin) to the Hyaluronic Acid gel base.
  4. Stir the mixture thoroughly until all ingredients are fully dispersed and combined. Ensure the temperature of the mixture is below 30°C during mixing.
  5. Check the pH of the final mixture to ensure it is within the range of 3.5-6.5, which is optimal for the stability of Argireline and Alpha Arbutin.

Storage and Shelf Life

  • Storage: For long-term stability of the active ingredients, the final mixture should be stored in the refrigerator at a temperature of 4°C to 8°C.
  • Shelf Life: The individual ingredients have a shelf life of at least 2 years when stored correctly in the refrigerator. Since the Hyaluronic Acid Gel Base you mentioned is preservative-free, it is highly recommended to add a suitable preservative to your mixture to prevent microbial growth and maintain stability. With proper storage in the refrigerator and the addition of a preservative, the mixture should have a shelf life of at least 1-2 years, but always observe for any changes in appearance, smell, or texture.

ผลิตภัณฑ์ที่เกี่ยวข้องที่กล่าวถึง

Acetyl Hexapeptide-8 (eq Argireline)
Acetyl Hexapeptide-8 (eq Argireline)
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Pal-GHK, Pal-GQPR (eq Matrixyl 3000)
Pal-GHK, Pal-GQPR (eq Matrixyl 3000)
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Alpha Arbutin (Switzerland)
Alpha Arbutin (Switzerland)
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Hyaluronic Acid (Standard Molecule, 1M Daltons)
Hyaluronic Acid (Standard Molecule, 1M Daltons)
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Alpha Arbutin (China, Powder, Enzymatic Synthesis)
Alpha Arbutin (China, Powder, Enzymatic Synthesis)
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Hyaluronic Acid Gel Base
Hyaluronic Acid Gel Base
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