Mixing Actives in Argan Oil Base: Compatibility, Solubility, and pH

ถามโดย: bomnamidang เมื่อ: November 01, 2021 ประเภทผลิตภัณฑ์: เครื่องสำอาง

คำถาม

I have a formulation consisting of Argan Oil as the base, mixed with oil-soluble Q10, Bakuchiol, Ascorbyl Tetraisopalmitate, and Ethoxydiglycol. I have mixed these by shaking. My questions are: 1. Can I add ActiveRelease Retinal™ to the above formula next time? 2. Is ActiveRelease Retinal™ oil-soluble? 3. When mixing the three active ingredients ActiveRelease Retinal™, Ascorbyl Tetraisopalmitate, and Bakuchiol in 100% Argan Oil, is pH adjustment not necessary? (I am concerned about instability and lack of benefit if not stable).

คำตอบ

Formulation Advice for Argan Oil Base

You have a formulation using Argan Oil as the base, mixed with oil-soluble Coenzyme Q10, Pure-Bakuchiol™, Perfect-C™ (Ascorbyl Tetraisopalmitate), and Ethoxydiglycol.

Here are the answers to your questions:

  1. Can ActiveRelease Retinal™ be mixed with the current formula?
    ActiveRelease Retinal™ (Retinal-EZ™) is an encapsulated form of Retinaldehyde designed to be water-dispersible and is typically mixed directly into water-based formulas. Your current formula is oil-based (100% Argan Oil base). Mixing a water-dispersible ingredient into a purely oil base may lead to issues with dispersion and long-term stability compared to its intended use in water formulas. While Ethoxydiglycol, which is soluble in both oil and water, is present and might help with dispersion, it is important to note that this ingredient is primarily recommended for water systems. However, the good news is that Pure-Bakuchiol™ in your formula has been shown to help stabilize Retinal.

  2. Is ActiveRelease Retinal™ oil-soluble?
    No, ActiveRelease Retinal™ (Retinal-EZ™) is not oil-soluble. It is an encapsulated form that is water-dispersible, meaning it is designed to be dispersed in water, not dissolved in oil.

  3. Do the active ingredients (ActiveRelease Retinal™, Ascorbyl Tetraisopalmitate, Bakuchiol) mixed in 100% Argan Oil need pH adjustment?
    pH adjustment is not necessary for a formula that is 100% oil-based, such as one using Argan Oil as the base. pH is a measure of acidity or alkalinity in water-based systems and is not relevant in pure oil formulations. The stability of oil-soluble or oil-dispersible ingredients in an oil base depends on other factors like protection from light, heat, and oxidation, rather than pH.

For optimal stability and efficacy, especially when incorporating ingredients like Retinal, always store the finished product in an opaque, airtight container and protect it from light and heat.

ผลิตภัณฑ์ที่เกี่ยวข้องที่กล่าวถึง

Argan Oil (Virgin - Deodorized)
Argan Oil (Virgin - Deodorized)
เครื่องสำอาง
Ethoxydiglycol (e.q. Transcutol)
Ethoxydiglycol (e.q. Transcutol)
เครื่องสำอาง
Perfect-C™ (Ascorbyl Tetraisopalmitate)
Perfect-C™ (Ascorbyl Tetraisopalmitate)
เครื่องสำอาง
Coenzyme Q10 (98%, Powder, Oil-Soluble)
Coenzyme Q10 (98%, Powder, Oil-Soluble)
เครื่องสำอาง
Pure-Bakuchiol™ (Natural Retinol, 99% Pure, USA)
Pure-Bakuchiol™ (Natural Retinol, 99% Pure, USA)
เครื่องสำอาง
Retinal-EZ™ (Encapsulated Water Dispersible Retinal)
Retinal-EZ™ (Encapsulated Water Dispersible Retinal)
เครื่องสำอาง