Formulation Advice and Product Information

Here are the answers to your questions regarding your cosmetic formulation and product inquiries:

1. Mixing Active Ingredients into Bases

Based on the active ingredients you wish to mix (Vitamin B3 4%, NAC 4%, Apple Stem Cell 2%, Sea Kelp 10%) and the bases you mentioned (Hada Labo Nano Hyaluron 80% and Avalon Vitamin C MAP 80%), both bases appear compatible for mixing these active ingredients.

• Hada Labo Nano Hyaluron Base: This is likely a water-based or gel-based product. Water-based formulas generally offer good absorption into the skin.
• Avalon Vitamin C MAP Base: You provided the ingredient list, and based on the analysis, adding the active ingredients seems compatible. This is a cream base, which might feel richer on the skin.

Choosing between the two bases depends on your preference for texture and feel. Water-based formulas tend to absorb quickly and feel lighter, which might be preferable if you layer other products. Cream bases provide more emollience and can be very moisturizing. Both can deliver the active ingredients effectively, but the overall formulation of the base product (beyond just the main ingredient) also plays a role in performance.

2. Layering Hyaluron and Vitamin C MAP Products

Generally, when layering skincare products, it's recommended to apply products from thinnest consistency to thickest. Water-based serums or gels are typically applied before creams or lotions.

• If you mix the active ingredients into the Hada Labo Nano Hyaluron base, you would typically apply this serum/gel first, followed by the Avalon Vitamin C MAP cream.
• If you mix the active ingredients into the Avalon Vitamin C MAP base, and you still wish to use a separate Hyaluron product (like a standalone Hyaluron serum), you would apply the standalone Hyaluron product first, followed by your custom-mixed Avalon Vitamin C cream.

3. Understanding Sea Kelp Percentage

The percentage usage rate for Sea Kelp Extract (5%-100%) refers to the concentration of the ingredient in the final product by weight. 100% means using the Sea Kelp Extract undiluted. To use Sea Kelp Extract at 10% in your formulation, you would need to calculate the weight of the Sea Kelp Extract based on the total weight of your final product.

For example, if you want to make 100 grams of your final product, and you want 10% Sea Kelp Extract, you would use 10 grams of Sea Kelp Extract and 90 grams of your base and other ingredients. The 20g package size is simply the quantity of the raw material you purchase.

4. Storage of Finished Product

For optimal stability and longevity of the active ingredients you are using, especially those like Pure-NAC, Apple Stem Cell Extract, Sea Kelp Extract, Magnesium Ascorbyl Phosphate, Nano Hyaluronic Acid, Acetyl Hexapeptide-8 (Argireline), Pal-GHK, Pal-GQPR (Matrixyl 3000), and Pep®-Leupha (Leuphasyl), refrigeration (storing in the refrigerator at 4-8°C) is highly recommended for long-term storage. While storing at room temperature away from direct sunlight might be acceptable for some ingredients or short periods, the cool temperature of a refrigerator helps to preserve the potency of many active cosmetic ingredients.

When traveling, exposing the product to heat for extended periods can accelerate the degradation of these sensitive active ingredients. If possible, keep the product in a cool place or a cooler bag during travel. For daily use at home, refrigeration is the best practice to ensure the ingredients remain effective for as long as possible.

5. Ready-to-Use Production Service

Yes, the lab is currently accepting ready-to-use mixing orders again. The estimated time for mixing your ready-to-use product with your desired active ingredients is approximately 5-7 days, depending on the current queue.

6. Adding Leuphasyl to Argireline + Matrixyl Cream

You previously provided the ingredient list for your cream containing Acetyl Hexapeptide-8 (Argireline) and Pal-GHK, Pal-GQPR (Matrixyl 3000). The staff reviewed this formula and advised that it is already a good formula for addressing wrinkles. While Pep®-Leupha (Leuphasyl) can potentially enhance the effect of Argireline, the staff suggested that the added benefit might not be substantial compared to the cost, given the existing effective ingredients in your cream. They recommended using your current cream consistently first.

If you still wish to add Pep®-Leupha (Leuphasyl), it is typically added directly into the cream base during the final mixing step, ensuring the temperature is below 40°C. A common usage rate for Pep®-Leupha is around 3%, but it can be used up to 10%. However, as advised, consider the potential added benefit versus the cost before adding it to your already effective formula.

7. Product Safety and Certification

MySkinRecipes is a distributor of raw cosmetic ingredients, not finished cosmetic products. Therefore, the raw materials themselves do not require FDA approval (อย.) in the same way that finished cosmetic products sold to consumers do. The responsibility for obtaining FDA notification (จดแจ้งสูตร) lies with the individual or company who purchases the raw materials and mixes them into a finished product for sale to the public.

MySkinRecipes adheres to quality standards, such as GMP (Good Manufacturing Practice), for the raw materials they distribute to ensure their quality and safety for use in cosmetic formulations. They also offer a service to assist customers with the FDA notification process if they purchase raw materials in large quantities for commercial production.

Thank you for your questions and Happy New Year 2556 to you too! (Note: 2556 in the Buddhist calendar corresponds to 2013-2014 in the Gregorian calendar.)