Mixing Azelaic Acid with AHA and Diluting Benzoyl Peroxide Products
Question
Can Azelaic Acid be mixed with AHA? What base should be used? Also, is it possible to dilute finished Benzoyl Peroxide products like Benzac by purchasing a separate base?
Answer
Mixing Azelaic Acid and AHA
Yes, it is possible to mix Azelaic Acid and AHA in a formulation, but it requires careful consideration of the pH and potential for skin irritation. Both ingredients can be potent, and combining them might increase the risk of irritation, especially for sensitive skin.
Azelaic Acid (Liquid Azelaic™) is a water-soluble form that can be incorporated into various bases such as gels, serums, lotions, or creams. According to the product information, it should be added in the final step of formulation at temperatures below 40°C, and the final product pH should be between 5 and 11.
AHAs typically require a lower pH (often between 3 and 4) to be most effective for exfoliation. When combining Azelaic Acid and AHA, you would need to formulate a base that can maintain a stable pH suitable for both ingredients, which can be challenging. The optimal pH range for the combined product would depend on the specific type and concentration of AHA used, as well as the desired efficacy and irritation profile.
For a base, you can use a standard lotion or cream base that allows for pH adjustment. However, it is crucial to perform stability testing and evaluate skin tolerance when combining these active ingredients.
Diluting Benzoyl Peroxide Products (like Benzac)
It is generally not recommended to purchase a separate base to dilute finished Benzoyl Peroxide products like Benzac. Pharmaceutical and cosmetic products are formulated with specific bases that ensure the stability, efficacy, and safety of the active ingredient at its intended concentration.
Diluting a finished product with an arbitrary base can disrupt the formulation, potentially leading to:
- Reduced Stability: The Benzoyl Peroxide might degrade faster.
- Decreased Efficacy: The active ingredient might not be delivered effectively to the skin.
- Increased Irritation: The altered formulation might become more irritating.
- Microbial Contamination: The added base might not be properly preserved.
If you require a lower concentration of Benzoyl Peroxide, it is best to look for commercially available products that are already formulated at the desired lower strength. If you are interested in formulating with Benzoyl Peroxide from scratch, it requires specific knowledge and appropriate bases designed for this ingredient, which may not be readily available or safe for home formulation.