Mixing Instructions and pH for Multi-Active Cream Formula
คำถาม
I have the following formula and would like guidance on the mixing procedure and whether I need to be concerned about the pH:
- MSH 5%
- n-acetyl glucosamine 4%
- Vitamin B3 2%
- Activated Resorcinol 1%
- B6 3%
- Zinc PCA 1%
- Argireline® 10%
- Matrixyl™ 3000 8%
- Water + Phenoxyethanol (1%) 65%
- Light Cream Maker 1%
Please advise on the mixing steps and if pH adjustment is necessary for this formula. Thank you.
คำตอบ
Mixing Instructions and pH for Your Formula
Here are the recommended steps for mixing your cosmetic formula, considering the properties of each ingredient:
Mixing Steps
- Prepare the Water Phase: Combine the Purified Water and Phenoxyethanol. Add the N-acetyl glucosamine and Vitamin B3 (Safe-B3™) to this phase and stir until fully dissolved. Avoid prolonged heating of this phase.
- Prepare the Oil Phase: You will need a small amount of a suitable oil (not specified in your formula, but required for dissolving MSH White and Activated Resorcinol). Combine the MSH White (Undecylenoyl phenylalanine) and Activated Resorcinol (4-Butyl Resorcinol) with this oil. Gently heat the oil phase to around 80°C to help dissolve the MSH White. Once dissolved, remove from heat and let it cool slightly before adding the Activated Resorcinol, as Activated Resorcinol should avoid heat. Add the Light Cream Maker™ to this oil phase and stir well.
- Combine Phases: Gradually add the Water Phase to the Oil Phase while stirring or blending continuously. Continue stirring until a smooth cream is formed.
- Cool Down Phase: Allow the cream to cool down to below 40°C.
- Add Peptides: Once the cream is below 40°C, add the Argireline® (Acetyl Hexapeptide-8) and Matrixyl™ 3000 (Pal-GHK, Pal-GQPR) and stir to incorporate.
- Add Electrolytes: Gradually add the Vitamin B6 and Zinc PCA, stirring well after each addition. Be aware that these ingredients are electrolytes and can potentially thin the cream consistency created by the Light Cream Maker™.
pH Consideration
Yes, you should definitely be concerned about the pH of this formula. Several ingredients in your formula have specific optimal pH ranges for stability and effectiveness:
- Activated Resorcinol: Optimal pH 4.5-5.5
- Vitamin B3 (Safe-B3™): Optimal pH 4.0-7.0
- N-acetyl glucosamine (GlucoBright™): Optimal pH 3-7
- Zinc PCA: Optimal pH 4-6
- Argireline®: Optimal pH 3.5-6.5
- Vitamin B6: Stable pH 2-6 (Note: Vitamin B6 itself is acidic and will lower the formula's pH)
Given these ranges, a final pH between 4.5 and 5.5 would be ideal to ensure the stability and efficacy of most of the active ingredients. Vitamin B6 is particularly acidic and will lower the pH, while Zinc PCA is best in the 4-6 range. Activated Resorcinol is most effective and stable around 4.5-5.5.
After mixing all ingredients, check the pH of your final product using a pH meter or pH strips. If the pH is outside the 4.5-5.5 range, you may need to adjust it using a suitable cosmetic-grade acid (like Lactic Acid) to lower the pH or a base (like Triethanolamine) to raise the pH, adding only a small amount at a time and re-checking until the desired range is reached.
ผลิตภัณฑ์ที่เกี่ยวข้องที่กล่าวถึง
Acetyl Hexapeptide-8 (eq Argireline)
Pal-GHK, Pal-GQPR (eq Matrixyl 3000)
Safe-B3™ (Vitamin B3, Niacinamide)
GlucoBright™ (Acetyl Glucosamine)
Light Cream Maker™
Phenoxyethanol (Extra Pure)
Zinc PCA
Activated Resorcinol™ (4-Butyl Resorcinol)
Vitamin B6 (Pyridoxine Hydrochloride)
MSH White™ (Undecylenoyl phenylalanine)