Regarding the use of Salmon DNA (PDRN, Polydeoxyribonucleotide, 95% Micronized Flake) in a cream base, here are the recommendations:

It is NOT recommended to mix PDRN flakes directly into a finished cream base without pre-dissolving them.

Here are the reasons why:

1. Dissolution Difficulty: This specific PDRN is in a micronized flake form. While it is water-soluble, it requires special tools (such as high-speed stirring or high pressure) to dissolve completely. Mixing it directly into a thick cream base will likely result in a "gritty" texture with undissolved particles, and the active ingredient will not be evenly distributed.
2. Efficacy: For PDRN to effectively penetrate the skin and provide its tissue-repairing and anti-inflammatory benefits, it must be properly dissolved and dispersed in the formula.

Correct Mixing Method:

• Dissolve in Water Phase: You should dissolve the PDRN flakes in the water portion of your formula first. Ensure it is completely clear and dissolved before combining it with other ingredients.
• Avoid Heat: PDRN is sensitive to heat. It should be mixed into the formula at room temperature or during the cooling phase (below 40°C) to maintain its stability.
• Usage Rate: The recommended usage rate is 0.3-0.8% (0.5% is generally recommended).

Summary: To ensure a smooth cream texture and maximum skin-repairing benefits, always dissolve the PDRN flakes in water before incorporating them into your cream base.