Mixing Safe-B3 and Adenosine in a Serum

Both Safe-B3 (Niacinamide) and Adenosine are water-soluble ingredients commonly used in serums. To incorporate them into a serum formulation, follow these general guidelines:

1. Prepare the Water Phase: Dissolve Safe-B3 and the chosen type of Adenosine (such as Adenosine Phosphate Disodium, which is water-soluble) in the water phase of your serum formulation.
2. Temperature: Safe-B3 is heat resistant, but some types of Adenosine, like Adenosine Phosphate Disodium, should avoid temperatures exceeding 40°C. It is best to dissolve both ingredients in the water phase at room temperature or with gentle warming below 40°C if necessary for dissolution.
3. pH Adjustment: Niacinamide (Safe-B3) is most stable and effective in a pH range of 4.0-7.0. Different types of Adenosine have varying pH requirements for solubility and stability. For instance, Pure-Adenosine™ is best dispersed in cream/gel at pH 3.5-6.5, while Adenosine Triphosphate dissolves in water at pH 6.8-7.4. Adenosine Phosphate Disodium is water-soluble and suitable for serums. Aim for a final serum pH that is compatible with both ingredients, ideally within the 4.0-6.5 range to suit Safe-B3 and common serum bases.
4. Combine Phases: Once the ingredients are fully dissolved in the water phase, combine it with any other phases (like oil phase if applicable, though serums are often primarily water-based) and add other components like thickeners, preservatives, and other active ingredients according to your full formulation.
5. Final Adjustment: After combining all ingredients, check and adjust the final pH of the serum to the desired range (e.g., 4.0-6.5) using a suitable acid or base.

Recommended Usage Rates:

• Safe-B3 (Niacinamide): Typically used at 1-10%. Safe-B3 types are high purity and can often be used up to 10% without causing flushing.
• Adenosine: Usage rates vary depending on the type. Pure-Adenosine™ is typically used at 0.1-1.0%, Adenosine Triphosphate at 1-5% (recommended 3%), and Adenosine Phosphate Disodium at 1-3%.

Always refer to the specific product's documentation for precise usage rates, solubility, and pH requirements to ensure optimal performance and stability in your formulation.