Mixing Skincare Serum Ingredients: Order and Compatibility
Question
I have the following liquid ingredients with their percentages: Pep-Coll (Palmitoyl Tripeptide-5) 5g (4.9%), Ethoxydiglycol 3g (2.9%), Acetyl Hexapeptide-8 10g (9.7%), Galactomyces Ferment Filtrate 55g (53.4%), Vitamin B3, Niacinamide 10g (9.7%), Repair Activator (Bifida Ferment Lysate) 20g (19.4%). All ingredients are in liquid form. Can they be mixed together and applied to the face? There are two ingredients that need to be mixed in the final step: Pep-Coll and Acetyl Hexapeptide-8. Which of these two should be mixed last? Please help, I'm new to mixing.
Answer
Mixing Your Serum Ingredients
Yes, based on the ingredients you listed – Pep-Coll (Palmitoyl Tripeptide-5), Ethoxydiglycol, Acetyl Hexapeptide-8, Galactomyces Ferment Filtrate, Vitamin B3 (Niacinamide), and Repair Activator (Bifida Ferment Lysate) – and their properties, you can mix them together to create a serum for your face. These ingredients are generally water-soluble and compatible in a liquid formulation.
Mixing Instructions
Several of these ingredients, particularly the peptides (Pep-Coll and Acetyl Hexapeptide-8), Galactomyces Ferment Filtrate, and Repair Activator, are sensitive to heat and should be added in the final mixing step.
Here is a general mixing guide:
- Combine ingredients that are less sensitive to temperature first, such as Ethoxydiglycol and Vitamin B3 (if it is in liquid form or has been pre-dissolved in water).
- Ensure the temperature of your mixture is below 40°C.
- In the final step, add the temperature-sensitive ingredients: Pep-Coll, Acetyl Hexapeptide-8, Galactomyces Ferment Filtrate, and Repair Activator.
- Mix gently until all ingredients are fully incorporated and the serum is homogeneous.
Regarding Pep-Coll and Acetyl Hexapeptide-8, both should be added during this final mixing phase below 40°C. You can add them together or one after the other in this step.
Always ensure your equipment is clean and sanitized before mixing.
Related Products Mentioned
Acetyl Hexapeptide-8 (eq Argireline)
Pep®-Coll (Palmitoyl tripeptide-5)
Safe-B3™ (Vitamin B3, Niacinamide)