Molecular Weight and Skin Penetration Properties of NAD+

Asked by: Anonymous On: March 10, 2026 Product Type: Cosmetics

Question

What is the molecular size of `NAD+`?

Answer

The molecular weight of NAD+ (Nicotinamide Adenine Dinucleotide) is approximately 663.43 g/mol (Daltons).

In cosmetic science, molecules with a molecular weight under 500 Daltons are generally considered to penetrate the skin barrier more easily. Since NAD+ is slightly above this threshold (663.43 Da), it is often formulated to support the skin's natural functions, such as:

  • Anti-aging: Supporting cellular energy and DNA repair.
  • Skin Barrier Support: Enhancing the skin's resilience and hydration.
  • Antioxidant Properties: Protecting the skin from oxidative stress and free radicals.

If you are looking for a high-purity NAD+ for cosmetic formulation, we recommend Pure-NAD+™ (Nicotinamide Adenine Dinucleotide), which is a 100% pure powder suitable for anti-aging products.

Usage Recommendations:

  • Usage Rate: 1-2%
  • Solubility: Water-soluble (mix in the water phase).
  • Storage: Keep in a tightly sealed container, away from direct sunlight and heat.

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