MSH White Solubility in Cream/Lotion and Alcohol Odor/Preservation

Based on the conversation, here is a summary of the answers provided:

Regarding MSH White:

• Yes, you can dissolve MSH White in the oil phase (like LipidSoft) at around 60°C. Since the oil phase doesn't have a pH, this avoids the issue of difficult dissolution in the pH range of 5-6.2.
• When dissolving MSH White in the oil phase and then emulsifying to create a cream or lotion, it is suitable because the MSH White remains within the oil droplets and does not interact with the water phase at the problematic pH.
• For 2% MSH White in a formula, it is recommended to use oil (such as LipidSoft) at a ratio of approximately 1:5 (MSH White : Oil). This means you should have at least 10% oil in your formula.
• Dissolving MSH White in water at a pH outside the 5-6.2 range and then adjusting the pH to 5-6 will cause precipitation.

Regarding Alcohol:

• All types of ethyl alcohol (ethanol) have a natural pungent smell; there is no type that is not pungent.
• The intensity of the smell in a cosmetic product depends on the concentration used. High concentrations (above 10%), like those often found in some sunscreens (e.g., Biore), will have a noticeable smell.
• To minimize the smell, try to keep the alcohol concentration below 5%. If using a higher concentration, you might need to use fragrance to mask the scent.
• The alcohol sold has the same disinfectant properties as alcohol sold in pharmacies. Using alcohol in your formula (e.g., at 5%) can help with preservation and may allow you to reduce the amount of other preservatives needed.