MSH White™ vs Activated Resorcinol™ for Whitening and Mixing with TransDerm Base

Asked by: n.sitang On: May 06, 2015 Product Type: Cosmetics

Question

Regarding skin whitening ingredients:

1. What are the differences between MSH White™ and Activated Resorcinol™ in terms of their mechanisms and effectiveness for skin whitening?
2. Is one ingredient superior to the other, or is it better to use them together for enhanced results, particularly for issues like age spots?
3. How should MSH White™ be properly mixed into a TransDerm base? Specifically, should it be dissolved in the oil phase, and if so, at what temperature and until what consistency?

Answer

MSH White™ vs Activated Resorcinol™ for Whitening and Mixing with TransDerm

Both MSH White™ and Activated Resorcinol™ are effective skin whitening agents, but they work through different mechanisms, making them complementary rather than one being strictly "better" than the other.

  • Activated Resorcinol™: Primarily works by inhibiting the enzyme Tyrosinase, which is crucial for melanin production, and also helps prevent pigment transfer within the skin.
  • MSH White™: Works by reducing the activity of Alpha-MSH, a hormone that stimulates melanin production. This different pathway makes it particularly effective for addressing age spots and other forms of hyperpigmentation.

Given their distinct mechanisms, using both MSH White™ and Activated Resorcinol™ together is recommended to achieve a more comprehensive and enhanced whitening effect, especially for stubborn pigmentation like age spots.

Regarding mixing MSH White™ with a TransDerm base, it can be incorporated into the oil phase of the base. MSH White™ is oil-soluble and should be dissolved in the oil part of your formulation using heat, typically around 80°C, until it is clear before proceeding to mix with the water phase and other ingredients.