Penetration Enhancer, UV Stabilizers, and Opaque Packaging for Formula Stability
Question
In a formula containing Phenylethyl Resorcinol, if a penetration enhancer like DMI is used, will it also increase the skin penetration of UV stabilizers/filters (e.g., ActiveProtec™ UV, BEMT) added for formula protection? Is this increased penetration safe, and can using an opaque bottle eliminate the need for these in-formula UV protectors?
Answer
Okay, let's break down your questions about using a penetration enhancer (DMI) with UV protectors (ActiveProtec™ UV, BEMT) in a formula containing Phenylethyl Resorcinol.
Will DMI cause UV protectors to penetrate the skin more easily?
Yes, penetration enhancers like DMI (Dimethyl Isosorbide) are designed to increase the skin's absorption of ingredients in a formulation. If ActiveProtec™ UV and BEMT are present in the formula that is applied to the skin, DMI can potentially enhance their penetration into the skin.Is increased penetration of these UV protectors dangerous?
ActiveProtec™ UV and BEMT in this context are likely used as UV stabilizers or absorbers within the formula itself to protect ingredients like Phenylethyl Resorcinol from degrading due to light exposure, not primarily as sunscreens for skin protection. While BEMT is a known UV filter used in sunscreens applied to the skin, increased penetration of formula stabilizers is generally not the intended outcome and could be undesirable. The safety profile of increased penetration would depend on the specific ingredient, its concentration, and the overall formulation. It's a factor that should be considered during safety assessment.Is an opaque bottle sufficient, eliminating the need for in-formula UV protectors?
Using an opaque bottle is a very effective way to protect the formula inside the bottle from external UV light exposure. If the primary stability issue for Phenylethyl Resorcinol is degradation caused by light during storage, then an opaque bottle can significantly reduce or potentially eliminate the need for UV protectors within the formula. However, in-formula UV protectors also offer some protection during the brief periods the product is exposed to light during use (e.g., when opening the bottle). The decision depends on the specific sensitivity of Phenylethyl Resorcinol and the desired level of stability throughout the product's lifecycle.
In summary, DMI can potentially increase the skin penetration of ingredients, including the UV protectors used for formula stability. While increased penetration of formula stabilizers might not be ideal, the safety depends on the specific ingredients. An opaque bottle is highly effective for protecting the formula from light during storage and can often reduce or remove the need for in-formula UV protectors if light sensitivity in the bottle is the main concern.