Preservative Requirement for Nano-TXA Serum Base with Niacinamide and Alpha Arbutin

Yes, you absolutely need to add a preservative to your serum.

Why a Preservative is Necessary

The Nano-TXA™ (Tranexamic Acid Nano Emulsion, Penetration Base) (ID: 33491) is a water-based system (a nano-emulsion dissolved in water). When you add other water-soluble ingredients like Niacinamide, Alpha Arbutin, and Hyaluronic Acid, the final product remains a water-based solution.

Any product containing water is highly susceptible to microbial growth (bacteria, yeast, and mold). Without a broad-spectrum preservative, your serum will spoil quickly, potentially within a week, and could pose a risk of skin infection.

Formulation Compatibility Check

Your proposed formulation is excellent for hyperpigmentation, and the ingredients are compatible with the Nano-TXA™ base:

• Nano-TXA™ Base (90%): This base is designed to carry water-soluble actives.
• Added Actives (Niacinamide, Alpha Arbutin, Hyaluronic Acid): These are all water-soluble and can be added directly to the Nano-TXA™ base.
• Total Addition Limit: The product description for Nano-TXA™ states you can add up to 10% of other water-soluble active ingredients. You must ensure the combined percentage of Niacinamide, Alpha Arbutin, Hyaluronic Acid, and your chosen preservative does not exceed 10% of the total formula.

Preservative Recommendation

You should choose a broad-spectrum preservative that is effective in the pH range of the Nano-TXA™ base (optimum pH 4.0-7.0).

A common and effective choice is Phenoxyethanol (Extra Pure) (ID: 155), often used at a concentration of 0.5% to 1.0%. For better broad-spectrum coverage, it is often paired with an ingredient like Ethylhexylglycerin.

Example Formulation Structure (Total 100%):

Always follow the specific usage instructions for your chosen preservative.